Should NAD+ (CHEBI:15846) be a purines (CHEBI:26401)

[hdrabkin]

Currently NAD salvage is not a child of purine-contatining compound salvage. We wonder if NAD+ should also be classified as a purine-containing compound (purines ChEBI:26401---A class of imidazopyrimidines that consists of purine and its substituted derivatives.). This categorization may be historical based on it originally being classified as a pyridine derivative. If so, NAD+ salvage (GO:0034355) will become a child of purine-containing compound salvage (this makes sense to us).

See https://github.com/geneontology/go-ontology/issues/21577

[amalik01]

Hi Harold, You're right that NAD+ should also come under the class 'purines' but looking at the ontology of nucleotides in ChEBI, there seems to be quite a few historical inconsistencies which also require fixing. I need to discuss these with some former colleagues before i fix this issue.

[hdrabkin]

Actually, it should also be a purine nucleotide...

[pgaudet]

Hi @amalik01

Any update on this?

[amalik01]

@hdrabkin @pgaudet I have added a new relationship to CHEBI:25524 (NAD(P) is a adenyl nucleotide) allowing all the child classes to be classified as purines. NAD+ is now also classified as a purine when you move up the ontology hierarchy. You will see these changes in ChEBI's next months release (1st September).

[pgaudet]

Thanks !

[hdrabkin]

So I can make NAD salvage is_a child of purine-contatining compound salvage now.

[hdrabkin]

We just checked in RHEA and NAD+ is actually NAD(1-), CHEBI:57540 presumably the pH 7.3 form Should CHEBI make NAD(1-) a purine-containing compound (purines ChEBI:26401