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[advice] adding new datasets to a reference dataset

Open cstrlln opened this issue 1 year ago • 0 comments

I was not sure where in the SCE community to ask but here it goes: Is there a tool to integrate new single cell datasets to a reference 'atlas' as to making the reference bigger?

I understand with SingleR I can use the information from the reference and give a known identity (cluster label) to the new cells. But I would like to add the new cells so that the previous representations (UMAP) are also transferred to the new cells. Something like scVI but in R.

In our work we sort and focus on a single type of cell and spend time curating a local reference dataset. Accruing the reference might be useful as more tools like geneformer emerger.

In any case any thoughts, advice on this would be great.

cstrlln avatar May 20 '24 14:05 cstrlln