Harmony data pre-processing and time connection

[pengyu1608]

Hi,

when I run harmony to load the data with: counts = harmony.utils.load_from_csvs(csv_files, sample_names)

I found that values greater than 32767 were transformed to negative value. It is noted that the default dtype is int16 (so the max allowed value is 32767). Should the value be adjusted larger?

And if I have multiple time points, should the time connection data frame look like this? 0 1 0 0 1 1 1 2 2 2 3 3 3 4 4 4 5 5 5 6 6 6 7