Dennis Hazelett

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This can be done with custom variants, e.g.: ``` chr1 12345 12349 chr1:12345:12349:ACTTG:AGTCG ```

If you change the strand you change the meaning of the bed file completely. For example if you indicate in your SNP label that the values are ":T:G", motifbreakR understands...

use MotifDb package; see [query function](http://rpackages.ianhowson.com/bioc/MotifDb/man/query.html)