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hicNormalize Behavior of operations on cool file

Open rysterzhu opened this issue 2 years ago • 1 comments

When hicNormalize normalizes cool, it seems use weight in cool for balance first, which results in most of the bin values becoming 0 when using the '-sz 1.0 --normalize smallest' parameter.I think that normalizing cool should be done without balance, or provide an optional parameter.

rysterzhu avatar Aug 29 '23 03:08 rysterzhu

Indeed, by default all tools in HiCExplorer will use weights if available. If you don't want to use them, please use hicConvertFormat with the option --load_raw_values to get a cool file without weights.

lldelisle avatar Sep 12 '23 07:09 lldelisle