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Biophysical properties of the clinical-stage antibody landscape

Open rbharath opened this issue 8 years ago • 1 comments

http://www.pnas.org/content/114/5/944.full

Contains a large (by standards of field :-)) dataset of all antibodies tested in phase-2 or phase-3 clinical trials measured "criteria regarding the feasibility of their manufacture, stability in storage, and absence of off-target stickiness."

This could be a valuable dataset for benchmarking antibody algorithmic techniques.

rbharath avatar Jul 20 '17 18:07 rbharath

"Great catch, @rbharath . This is a highly valuable reference. The PNAS dataset of 137 clinical-stage antibodies with $\approx12$ developability metrics (e.g., $\text{Tm}, \text{PSR}, \text{HIC}$) would be an excellent, high-value set for benchmarking our current $\text{ML}$ models. I propose we create a dedicated branch to integrate this data and compare our in silico predictions against the published experimental values to see how accurately we are predicting real-world developability risks."

ChinmayRout9040895625 avatar Oct 25 '25 05:10 ChinmayRout9040895625