dcjones
Cell Type Fusions
Recently, it has been published that monocytes and macrophages fuse to form giant macrophages. Will ProSeg handle it?
HNSCC also contains macrophages that exhibit a large cytoplasm and multiple nuclei, termed multinucleated giant cells (MGC).
Source: TREM2-Expressing Multinucleated Giant Macrophages Are a Biomarker of Good Prognosis in Head and Neck Squamous Cell Carcinoma, Cancer Discovery
The main difficulty proseg would have with these cases (and multi-nucleated cells in general) is that it is initialized and constrained by prior cell segmentation. If it's initialized with nuclear segmentation, as it typically is, these will be erroneously treated as multiple cells. But if a more sophisticated prior segmentation is used, proseg shouldn't have an issue here.
