Imaging Mass Cytometry is Unsupported

[DarioS]

Keen for --IMC to appear in a future version.

[dcjones]

Thanks for the interest! IMC data is pretty different than transcriptomic data and would involve a different set of assumptions in the model, so it isn't trivial to add support, but it may be something I explore down the line.

[DarioS]

Oh, what is the main difference? I do not know much about either assay. Is there a review which contrasts them?

[dcjones]

The biggest issue is just RNA vs protein more than anything. Proseg takes advantage of the fact most RNA is distributed fairly randomly throughout the cell to segment transcriptomic data. There is generally much more subcellular localization of protein than RNA, so this assumption would be more tenuous when applied to a protein assay.