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New form of variation (I think) - non-reciprocal homoeologous exchange

Open agolicz opened this issue 1 year ago • 4 comments

Hi Davide, This is really a feature request. We've been using VISOR and it has been great! We are working on a polyploid (allo-tetraploid) plant genome - Brassica napus. This means that it carries two sets of diploid, distinct, but closely related sub-genomes. It has a special type of variation - non-reciprocal homoeologous exchange, where several hundred of kbs to mbs from one sub-genome replace corresponding sequence in the other sub-genome, but the exchange is non-reciprocal, so the one of the sequences is completely lost. It would be incredibly helpful to us to be able to simulate this. If it helps we only hope to test the effect of this in completely inbred individuals - the sub-genomes are completely homozygous (as depicted on image attached). I know you are likely extremely busy, but if you could help that would be amazing! All the best, Agnieszka Screenshot 2023-02-03 142511

agolicz avatar Feb 03 '23 13:02 agolicz