ESP
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Replace normalizers w/ calibrators (that have no calibration samples)?
We could model our current normalizers as calibrators that have no calibration processes / samples. We could even overload useCalibrator() to accept a function and create the Calibrator object internally.
This would mean removing the ability to use both a normalizer and a calibrator, but that might be a good thing. I'm not sure when you'd need both, and it seems confusing to provide them both without being able to explain when you'd use which.