Precomputing a sample × mutation-in-gene-set matrix

[stephenshank]

At the 8/23 meetup, @dhimmel expressed interest in incorporating metabolic pathway information by combining the dataset that we have and the hetnet database that was described at the first meetup. The hetnet has information on what pathways the mutated genes in the current dataset participate in.

I figured I'd open this issue to get the conversation started. Initially, I am wondering what this dataset would look like, and do we envision it being created from what we already have? And how much tweaking will the classifier of the machine learning group (for instance, that provided by @gwaygenomics) require?