Custom macros will only take effect after restarting the editor

[smallmain]

Cocos Creator version

3.8.2-beta

System information

MacOS

Issue description

rt.

Relevant error log output

No response

Steps to reproduce

• Add a custom macro and print.
• If there is no problem with printing, delete this custom macro and print again.
• If there is no problem printing, add another one and print.

There is always a situation where there will be a problem.

Minimal reproduction project

No response