Using Heterozygous only model

[ruowangli]

Hi, I would like to use the "het - Heterozygous only model, code as 0/1/0" function in PRSice. However, I am wondering what would be the best corresponding plink GWAS result file to use as the input. In plink 2.0, both the genotypic and hetonly flags produce GWAS results under the 0/1/0 coding. Does PRSice work with both sets of result files? Thanks!

[choishingwan]

We've not perform any research on that actually. But I'd imagine using a GWAS on her effect will be the best, though using the additive one should not be too problematic either. It all depends on what you've got

Sam

On Wed, Aug 31, 2022, 9:07 PM ruowangli @.***> wrote:

Hi, I would like to use the "het - Heterozygous only model, code as 0/1/0" function in PRSice. However, I am wondering what would be the best corresponding plink GWAS result file to use as the input. In plink 2.0, both the genotypic and hetonly flags produce GWAS results under the 0/1/0 coding. Does PRSice work with both sets of result files? Thanks!

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