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Published 20 hours ago • verified publisher icon chhylp123

Mitigate Overlapping Sequence Assignments in Haplotypes

Open xuxingyubio opened this issue 4 months ago • 3 comments

Hi I've encountered an issue when assembling the MHC region using individual HiFi data. I noticed that some sequences are assigned to both hap1 and hap2. For instance, hap1 assembled two different alleles for HLA-DRB1, but one of these alleles also appeared in hap2, meaning that an additional allele was assigned to hap1. Is there any method or strategy that could mitigate the occurrence of such a situation?

xuxingyubio avatar Mar 26 '24 02:03 xuxingyubio