hifiasm
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Suggestion for using HiC
Hi!
We are planning to sequence a whole bunch of matching samples from Tumor-Normal pairs. My question is should we sequence HiC for all the sample-sets (incl tumors) or should we sequence HiC from a single normal sample if our end goal isn't to scaffold but to just phase the assemblies?
If we were to sequence HiC for all the samples at a lower coverage ~ 20-30x be fine?