whether is normal hic contacts of two haplotypes ?

[JiaoLaboratory]

Dear hifiasm develpoer; I have used hifiasm and hic data to generate two haplotype contigs, and then used 3DDNA generated chromosomal-level haplotypes for a diploit genome (2x =500M, het=0.6%) ; The hic contacts looks like this: I have no idea whether it is normal hic contact,? why do two haplotypes (i.e. chr1 and chr8 ) perform so much strong hic interaction ? I mean the hic contacts between the two haplotypes is abnormal, whether or not? Thank U for your advice ! @lh3 @chhylp123

[chhylp123]

It is hard to say. Probably you could follow the blog here: https://github.com/baozg/phased-assembly-check. I think it is reasonable, especially for debugging Hi-C phased assemblies.