Memory error or something else?

[kkakosim]

Hi, I am fitting a baseline in a large dataset (52k points) with a memory error:

....julia\packages\PyCall\tqyST\src\pyfncall.jl:43 =# @pysym(:PyObject_Call), PyPtr, (PyPtr, PyPtr, PyPtr), o, pyargsptr, kw))))) <class 'MemoryError'> MemoryError((51752, 51752), dtype('float64'))...

the function call and arguments seem to be ok because it completes with way less data (~1k). Because of large gradients (sharp peaks) I would like to avoid decimating or smoothing the data. Is this a memory issue or something else? (Julia v1.5.1, Win10: 16GB RAM)