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Curated list of open-access databases with human structural MRI data

openMorph

Curated list of open-access databases with human structural MRI data.

Feel free to make additions/updates via pull requests!

For an overview of benefits and considerations related to using open-access data for brain morphology research, see Madan (2017) Front Hum Neurosci [10.3389/fnhum.2017.00405].

ADNI

  • Alzheimer’s Disease Neuroimaging Initiative
  • http://adni.loni.usc.edu
    • older adults; dementia; longitudinal
    • T1, T2, DTI, ASL, rs-fMRI
  • Mueller et al. (2005) Alzheimers Dement [10.1016/j.jalz.2005.06.003]
  • Jack et al. (2008) J Magn Reson Imaging [10.1002/jmri.21049]

ABIDE

  • Autism Brain Imaging Data Exchange
  • http://fcon_1000.projects.nitrc.org/indi/abide/
    • N=1112
    • developmental; autism
    • T1, rs-fMRI
  • Di Martino et al. (2014) Mol Psychiatry [10.1038/mp.2013.78]

ADHD-200

Age-ility

AIBL

  • Australian Imaging, Biomarkers and Lifestyle
  • http://www.aibl.csiro.au
    • N=1100
    • older adults; dementia; longitudinal
    • T1, PD, T2, DWI, FLAIR, SWI
  • Ellis et al. (2009) Int Psychogeriatr [10.1017/S1041610209009405]

BRAINS

CamCAN

CMI-HBN

  • Child Mind Institute Healthy Brain Network
  • http://fcon_1000.projects.nitrc.org/indi/cmi_healthy_brain_network/
    • N=664 (goal of 10,000)
    • developmental (aged 5-21)
    • T1, T2, DKI, rs-fMRI, EEG
  • Alexander et al. (2017) bioRxiv [10.1101/149369]

COBRE

  • Center for Biomedical Research Excellence
  • http://cobre.mrn.org
  • http://fcon_1000.projects.nitrc.org/indi/retro/cobre.html
    • N=72 patients, 75 healthy controls
    • schizophrenia; lifespan
    • T1; rs-fMRI

CoRR

  • Consortium for Reliability and Reproducibility
  • http://fcon_1000.projects.nitrc.org/indi/CoRR/html/
    • N=1629
    • young adults; test-retest
    • T1, rs-fMRI, some DTI
  • Zuo et al. (2014) Sci Data [10.1038/sdata.2014.49]

DLBS

  • Dallas Lifespan Brain Study
  • http://fcon_1000.projects.nitrc.org/indi/retro/dlbs.html
    • N=315
    • lifespan; behavior
    • T1, PET

fBIRN

  • Function Biomedical Informatics Research Network
  • http://www.birncommunity.org
    • schizophrenia; test-retest; traveling subjects
  • Keator et al. (2016) NeuroImage [10.1016/j.neuroimage.2015.09.003]

GSP

  • Brain Genome Superstruct Project
  • http://neuroinformatics.harvard.edu/gsp/
    • N=1570
    • young adults; test-retest; behavior
    • T1, rs-fMRI
  • Holmes et al. (2015) Sci Data [10.1038/sdata.2015.31]

HCP

  • Human Connectome Project
  • http://humanconnectome.org
    • N=1200
    • young adults; behavior
    • T1, T2, rs-fMRI, task fMRI, Q-Ball
  • Van Essen et al. (2013) NeuroImage [10.1016/j.neuroimage.2013.05.041]
  • Glasser et al. (2016) Nat Neurosci [10.1038/nn.4361]

IXI

  • Information eXtraction from Images
  • http://brain-development.org/ixi-dataset/
    • lifespan
    • T1, T2, PD, MRA, DTI

Kirby 21

Maastrict 7T 700μm

  • https://zenodo.org/record/1117858
    • T1w, PDw, T2*w images, n=5, age range 24-30, no medical condition
    • MP2RAGE (T1, UNI, INV1, INV2) and T2*w (Multi-echo 3D GRE, TE1/TE2/TE3/TE4 = 2.53/7.03/12.55/20.35 ms) images, n=4, age range 24-58, no medical condition
  • Gulban et al. (2018) 10.1371/journal.pone.0198335

MASSIVE

  • Multiple Acquisitions for Standardization of Structural Imaging Validation and Evaluation
  • http://massive-data.org/index.html
    • N=1
    • multiple dMRI aquisitions
    • T1, T2, DWI, FLAIR
  • Froeling et al. (2016) [10.1002/mrm.26259]

Mindboggle-101

  • Mindboggle-101 data consist of three data sets:
    • N=101 individually labeled human brain surfaces and volumes
    • templates (unlabeled images combining the individual brains, used for registration)
    • atlases (anatomical labels combining the individual brains, used for labeling)
  • http://www.mindboggle.info/data.html
  • Data: https://osf.io/nhtur/; Labels: http://mindboggle.info/labels.html
  • Klein & Tourville (2012) [10.3389/fnins.2012.00171]

MIRIAD

  • Minimal Interval Resonance Imaging in Alzheimer's Disease
  • https://www.ucl.ac.uk/drc/research/methods/miriad-scan-database
    • N=69
    • longitudinal
    • T1
  • Malone et al. (2013) [10.1016/j.neuroimage.2012.12.044]

MPI-LMBB

  • MPI-Leipzig Mind-Brain-Body
  • https://openfmri.org/dataset/ds000221/
  • https://www.nitrc.org/projects/mpilmbb/
    • N=320
    • behavior
    • T1, T2, DWI, rs-fRMI
  • Mendes et al. (2017) [10.1101/164764]

MSC

  • Midnight Scan Club
  • https://openfmri.org/dataset/ds000224/
    • N=10
    • T1, T2, MRA, MRV, rs-fMRI, task fMRI
  • Gordon et al. (2017) Neuron [10.1016/j.neuron.2017.07.011]

NACC

  • National Alzheimer's Coordinating Center
  • https://www.alz.washington.edu
    • lifespan; dementia; longitudinal
    • T1, T2, DTI, FLAIR
  • Morris et al. (2006) [10.1097/01.wad.0000213865.09806.92]

NCANDA

  • National Consortium on Alcohol and Neurodevelopment in Adolescence
  • http://ncanda.org
  • https://www.niaaa.nih.gov/research/major-initiatives/national-consortium-alcohol-and-neurodevelopment-adolescence#Data
    • N ~ 800
    • adolescence, alcohol, development, longitudinal
    • T1, DTI, rs-fMRI
  • Brown et al. (2015) [10.15288/jsad.2015.76.895]

NKIRS

  • Nathan Kline Institute - Rockland Sample
  • http://fcon_1000.projects.nitrc.org/indi/enhanced/
    • N=683 (and counting)
    • developmental; lifespan; behavior
    • T1, DTI, rs-fMRI
  • Nooner et al. (2012) [10.3389/fnins.2012.00152]

OASIS cross-sectional

  • Open Access Series of Imaging Studies
  • http://www.oasis-brains.org
    • N=416
    • lifespan; dementia; test-retest
    • T1 only
  • Marcus et al. (2007) J Cogn Neurosci [10.1162/jocn.2007.19.9.1498]

OASIS longitudinal

  • Open Access Series of Imaging Studies
  • http://www.oasis-brains.org
    • N=150
    • older adults; longitudinal; dementia
    • T1 only
  • Marcus et al. (2010) J Cogn Neurosci [10.1162/jocn.2009.21407]

OpenNeuro (former OpenfMRI)

PING

  • Pediatric Imaging, Neurocognition, and Genetics
  • http://pingstudy.ucsd.edu
    • N=1493
    • developmental; behavior
    • T1, T2, DTI, and rs-fMRI
  • Jernigan et al. (2016) NeuroImage [10.1016/j.neuroimage.2015.04.057]

PNC

PTBP

  • Pediatric Template of Brain Perfusion
  • https://figshare.com/articles/PTBP_Nifti/1190933
    • N=210
    • T1, dMRI, rs-fMRI, ASL
  • Avants et al. (2015) [10.1038/sdata.2015.3]

SALD

  • Southwest University Adult Lifespan Dataset
  • http://fcon_1000.projects.nitrc.org/indi/retro/sald.html
    • N=494
    • lifespan
    • T1, rs-fMRI, task fMRI (subset)
  • Wei et al. (2017) bioRxiv [10.1101/177279]

SchizConnect

studyforrest

  • http://studyforrest.org
    • N=20
    • T1, T2, dMRI, SWI, angiography
    • up to 10+ hours of 7T and 3T fMRI per subject (2h hollywood movie [audio and/or audio-visual], localizers, retinotopic mapping, with simult. cardiac/resp, partially with simult. eyetracking)
      • extensive movie stimulus annotations
    • musical education, visual acuity, visual sensitivity
  • Hanke et al. (2014) [10.1038/sdata.2014.3]

T1-250μm

  • http://hiresmri.ovgu.de
    • N=1
    • T1 (250 μm resolution)
  • Lüsebrink et al. (2017) Sci Data [10.1038/sdata.2017.32]

TICV and Posterior Fossa Dataset

  • https://www.nitrc.org/frs/download.php/9386/TICV_BC2atlases_20160823.zip
    • N = 20
    • T1w Scans with manual annotations of Intracranial Vault and Posterior Fossa + 133 more brain regions manually annotated
    • Orig MRI files distributed via neuromorphometrics.org
  • Huo et al (2017) [10.1002/hbm.23432]

Test-Retest Reliability of Brain Volume Measurements

  • https://openfmri.org/dataset/ds000239/
  • https://figshare.com/collections/Test_Retest_Reliability_of_Brain_Volume_Measurements/929651
    • N=3, each scanned 40 times within 31 days
    • T1
  • MacLaren et al. (2014) [10.1038/sdata.2014.37]

UK Biobank

  • http://imaging.ukbiobank.ac.uk
    • N>10,000 (target=100,000)
    • lifespan; behavior; health
  • Miller et al. (2016) [10.1038/nn.4393]
  • Alfaro-Almagro et al. (2016) [10.1101/130385]

Download the Data

CoRR Download

The download_corr.ipynb jupyter notebook contains a script to webscrape the CoRR website and download the appropriate datasets.

Conda Environment

The conda_env.yml file contains the environment used to run the jupyter notebook. To create a conda environment from that file, execute conda env create -f conda_env.yml

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Curated list of open-access databases with human structural MRI data

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