Aggarwal et al. - Clinical and Genomic Characterization of Treatment-Emergent Small-Cell Neuroendocrine Prostate Cancer: A Multi-institutional Prospective Study

[SRodenburg]

https://pubmed.ncbi.nlm.nih.gov/29985747/

Study on treatment-emergent small-cell neuroendocrine prostate cancer (t-SCNC) (n=202), includes targeted DNA-Seq and RNA-Seq. Clinical data needs to be requested at the authors.

• [x] create an issue on datahub before curating a study (one issue per study) and copy this checklist to the issue tracker
• [ ] List information of the dataset/paper in the issue, e.g. pmid, paper link, suppl file link
• [ ] Document the curation process, e.g. how and by whom the data was transformed
• [ ] Follow the data checklist
• [ ] Create a pull request to datahub once the data is curated
• [ ] Push to triage portal
• [ ] Import into msk and public portal database
• [ ] Update the default quick select study list see https://github.com/cBioPortal/cbioportal/issues/5831 (only for studies that are not overlapping with existing ones; only for human tumors, not cell lines)
• [ ] Update cBioPortal news

[rmadupuri]

Data Available:

• RNA-seq for 119 samples (hg38) - Supp 2
• Variant calls from selected subset of genes (hg19) - Supp 3

Data Missing:

• Clinical/survival data
• Targeted sequenced gene list (23 genes per supp 3?)

[egarcialara]

• Clinical data for 119 samples available in https://github.com/DavidQuigley/WCDT/blob/master/clinical_metadata/2021_11_21_JCO_2018.txt

• Older version of this issue in https://github.com/cBioPortal/datahub/issues/265