Alumkal et al. - Transcriptional profiling identifies an androgen receptor activity-low, stemness program associated with enzalutamide resistance

[SRodenburg]

https://www.pnas.org/doi/10.1073/pnas.1922207117

Phase II trial - study on castration-resistant prostate cancer (CRPC) (n=36). Targeted DNA-sequencing on 26 of 36 biopsies, and RNA-Seq was performed on 25 of 36 biopsies.

We will need to ask the authors to release the sequencing data.

• [x] create an issue on datahub before curating a study (one issue per study) and copy this checklist to the issue tracker
• [ ] List information of the dataset/paper in the issue, e.g. pmid, paper link, suppl file link
• [ ] Document the curation process, e.g. how and by whom the data was transformed
• [ ] Follow the data checklist
• [ ] Create a pull request to datahub once the data is curated
• [ ] Push to triage portal
• [ ] Import into msk and public portal database
• [ ] Update the default quick select study list see https://github.com/cBioPortal/cbioportal/issues/5831 (only for studies that are not overlapping with existing ones; only for human tumors, not cell lines)
• [ ] Update cBioPortal news

[sbabyanusha]

Data Available:

RNA-seq for 25 samples (hg19) - Dataset_S01

Data Missing:

Clinical/survival data Mutation data

[stale[bot]]

This issue has been automatically marked as stale because it has not had recent activity. It will be closed if no further activity occurs. Thank you for your contributions.

[sbabyanusha]

This issue is being closed as we couldn't get a response from the author.