cbioportal icon indicating copy to clipboard operation
cbioportal copied to clipboard

cBioPortal mutation Visualize 3D Structure button failing

Open sheridancbio opened this issue 6 months ago • 0 comments

When attempting to Visualize 3D Structure from the mutations tab of the results page, the 3d molecular model pdb file fails to be downloaded from the rcsd pdb website.

Browser console errors such as this are seen: Failed to load resource: net::ERR_NAME_NOT_RESOLVED mmtf.rcsb.org/v1.0/full/2FEJ:1 (this was from a query of gene TP53 against the mskimpact study).

The problem seems to be that the web service at mmtf.rcsb.org has been discontinued as of July 2, 2024. see: https://www.rcsb.org/news/feature/65a1af31c76ca3abcc925d0c

It is recommended that clients switch to accessing pdb structure files in a new format called BCIF (rather than mmtf)

The cbiportal frontend should be updated to retrieve the structure files in the new format. I've searched the cbioportal-frontend repo and it seems that all references to mmtf are located within node_modules/3dmol ... so I think that dependency must be updated. We seem to be running version 1.3.7 (6 years old), and the current version seems to be 2.3.0

sheridancbio avatar Aug 16 '24 20:08 sheridancbio