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Add regional missense constraint OE to variant page

Open ch-kr opened this issue 1 year ago • 0 comments

Sam and I received feedback from clinical geneticists that they would like to be able to access regional missense constraint information from the variant pages. Would it be possible to add a table with RMC information to the variant pages similar to the genomic constraint table? image This table would have three types of displays:

  1. Variants in genes that weren't searched for RMC should have text saying they weren't searched (same text from the gene page view; e.g. ANKRD11)
  2. Variants in genes that were searched but don't contain evidence of RMC should have text indicating that gene had no evidence of RMC
  3. Variants in genes with evidence of RMC should have the coordinates of the RMC region displayed, the observed missense, expected missense, and observed/expected missense for that region. The table should also display the p-value associated with the region's significance and the OE scale. Please see below (and ignore the potato quality of the quick mockup): image

ch-kr avatar Feb 01 '24 18:02 ch-kr