gnomad-browser
gnomad-browser copied to clipboard
Add regional missense constraint OE to variant page
Sam and I received feedback from clinical geneticists that they would like to be able to access regional missense constraint information from the variant pages. Would it be possible to add a table with RMC information to the variant pages similar to the genomic constraint table?
This table would have three types of displays:
- Variants in genes that weren't searched for RMC should have text saying they weren't searched (same text from the gene page view; e.g. ANKRD11)
- Variants in genes that were searched but don't contain evidence of RMC should have text indicating that gene had no evidence of RMC
- Variants in genes with evidence of RMC should have the coordinates of the RMC region displayed, the observed missense, expected missense, and observed/expected missense for that region. The table should also display the p-value associated with the region's significance and the OE scale. Please see below (and ignore the potato quality of the quick mockup):