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negative CNN_1D scores

Open MarionFresquet opened this issue 8 months ago • 2 comments

Hello,

I used the Sarek pipeline to detect germline variants ( working with 30X WGS). After variant calling with haplotypecaller, the pipeline runs CNNScoreVariants and FilterVariantTranches. However, the number of variants in the filtered and unfiltered VCF files is the same.

When I checked the CNN_1D scores in the INFO section, most were negative, like -4.993, -5.226, 0.447; -7.3, -3.864, -8.959...

is this normal as an output of CNNSCOREVARIANTS ?

Thank you for your help !

MarionFresquet avatar Feb 04 '25 16:02 MarionFresquet