mychem.info icon indicating copy to clipboard operation
mychem.info copied to clipboard

'Indications' appearing as adverse drug reactions in AEOLUS data

Open mbrush opened this issue 7 years ago • 13 comments

Wanted to follow up with a question we discussed offline about AEOLUS data, which describe adverse drug reactions (ADRs), using meddra terms to codify the adverse outcomes. Specifically, I noted the inclusion of 'outcomes' in the mydrug AEOLUS data that seem to be primary indications for a drug (i.e. what it is used to treat), rather than adverse drug reactions.

For example, the mydrug results for imatinib, which is used to treat various leukemias, and outcomes include things like "Leukaemia", "Chronic lymphocytic leukaemia", "Acute leukaemia".

In your parsing of AEOLUS data, was there any metadata that would tell you what medrra terms represent indications for a particular drug so these could be filtered from the results, or at least tagged as being indications rather than adverse reactions to the drug? This would be a significant improvement to the dataset you generate.

mbrush avatar Apr 06 '17 18:04 mbrush