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Mappings to the biolink:"similar to" relationship

Open colleenXu opened this issue 3 years ago • 0 comments

Is your feature request related to a problem? Please describe. How to model the relationship where two things are similar to each other due to shared annotations/associations with other things

Describe the solution you'd like It's not clear to me if this is how the "biolink:similar_to" relation is meant to be used. Clarification on this would help.

I ended up picking "is comparable to" (SIO:000736) to model the disease-disease associations in DisGeNET, which are based on whether two diseases have annotations to the same genes and/or variants. What helped me make this decision:

  • ObjectProperty has the root, "is related to"
  • Description: "is a relation between two entities that share at least one feature whose value can be compared." See http://www.ontobee.org/ontology/SIO?iri=http://semanticscience.org/resource/SIO_000736

This SIO ObjectProperty is not in the biolink relation mappings.

What working group (or team) did this request originate from? Service Provider / Exploring Agent

Additional context Other relations that I looked at as options, but had issues with:

  • RO:HOM0000000 "in similarity relationship with". Doesn't have a root. Does appear to be more commonly used. See http://www.ontobee.org/ontology/RO?iri=http://purl.obolibrary.org/obo/RO_HOM0000000
  • NCIT:R116 "Disease may have associated disease". Its name sounds like it matches our need, but its description basically describes a situation where Disease A may sometimes occur with Disease B. This kind of statement isn't supported by this dataset, since this data isn't really looking at some kind of disease co-occurrence/co-morbidity. http://www.ontobee.org/ontology/NCIT?iri=http://purl.obolibrary.org/obo/NCIT_R116
  • MONDO:disease_shares_features_of (no ID number?) Its name looks right, but the annotations look like a subset-disease -> main-disease relationship. http://www.ontobee.org/ontology/MONDO?iri=http://purl.obolibrary.org/obo/mondo%23disease_shares_features_of
  • NCIT:R126 "Disease has associated disease". Its name looks right, but the annotations look like a subset-disease -> main-disease relationship. https://www.ebi.ac.uk/ols/ontologies/ncit/properties?iri=http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_R126 http://www.ontobee.org/ontology/NCIT?iri=http://purl.obolibrary.org/obo/NCIT_R126

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colleenXu avatar Nov 05 '20 20:11 colleenXu