Strategies using MOFA for integrating proteomic and CyTOF data

[pdimitron]

Hello,

I had a general question about using MOFA. I recently tried using MOFA to explore some proteomic (359 features) and CyTOF (37 features) in a cohort of 89 patient specimens. The data were normalized separately and I'm getting no factors that have explained variance from both assays. I'm pretty new to MOFA but I've been reading that sometimes when one assay has many more features this might affect the weights. I wanted to know if there were alternative strategies I could try to tease out subtler differences in variation.

Thanks! Peter