pyMSA
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Negative entropy?
Just noticing that your formula for entropy doesn't have the negative sign: https://github.com/benhid/pyMSA/blob/570d902bbc214a30f18b93adf735c46836611bf5/pymsa/core/score.py#L84
So an MSA that is high entropy (ie very random) will appear as a large negative number, which is a bit confusing, when instead it should be a large positive number.