amr_curation

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BioF class B2 beta-lactamase should get a PFM allele number ?

1

A paper describing a new class B2 beta-lactamase named BioF has just come out ("BioF is a novel B2 metallo-β-lactamase from _Pseudomonas_ sp. isolated from an on-farm biopurification system", Environ...

iorga

Question on sequence update of mecC-type BlaZ gene in CARD v 3.1 to 3.2

1

Hello! I have a question about a sequence update (details below) and was curious to learn more about how the decision was made to update this sequence / the evidence...

katrinakalantar

lnuB and lsaE are identical

1

Hi, the sequences of lnuB and lsaE are identical. Should these be merged? Thanks, Michael

MBiggel

CARD (ARO:3004134) suspiciously prevalent in H pylori. Second opinion?

2

Hi all, This is referring to the entry for Helicobacter pylori 23S rRNA with mutation conferring resistance to clarithromycin (ARO:3004134) https://card.mcmaster.ca/ontology/41261 I noticed that when I uploaded 10 strains (only...

SJohnsonMayo

Identification of 76 novel B1 metallo-β-lactamases through large-scale screening of genomic and metagenomic data

3

@danielhhaft we've been reviewing [Identification of 76 novel B1 metallo-β-lactamases through large-scale screening of genomic and metagenomic data](https://pubmed.ncbi.nlm.nih.gov/29020980/). The authors identify 77 putative beta-lactamases by using novel HMMs. Attached are...

agmcarthur

Official abbreviations for antibiotics/drugs

4

[EUCAST_system_for_antimicrobial_abbreviations.pdf](https://github.com/arpcard/amr_curation/files/3765111/EUCAST_system_for_antimicrobial_abbreviations.pdf) Should we consider adding or using the 3 letter EUCAST codes for drug names to the ARO ?

tseemann

Hi, Thank you for the CARD database, it is very helpful. I have one question: I am using the software version and the output we get is xyz ARF present...

pdhrati02

This is prompted by a question to NCBI: "This protein is AAC(6')-IId and should not be called AAC(6')-Ib4. The protein contains a Leu to Ser change at aa 102 (DQLLA->DQSLA)...

feldgard

Klebsiella pneumoniae KpnEF is annotated as being an **MFS** family efflux pump. However, the citation given in the "Publications" box associated with the item says it's an **SMR** family efflux...

dannagifford

fabG1 mutation in card web, but not in card.json?

1

hi sir: fabG1 mutation is a very important event in Mycobacterium tuberculosis Resistance，but not in card.json，so RGI will not work on this gene?

feihongloveworld