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How to understand the result of dyn.pl.jacobian in tutorial?

Open FionaMoon opened this issue 3 years ago • 0 comments

Hi dynamo group,

I'm learning dynamo following the tutorial and I'm confused of the result of this code: dyn.pl.jacobian(adata, regulators=['tfec'], effectors=['pnp4a'], basis='umap') # https://dynamo-release.readthedocs.io/en/latest/notebooks/Differential_geometry.html

I don't know how to understand the explaination of the result in tutorial.

The tutorial shows pnp4a is activated by tfec: In iridophore cells, we found that pnp4a was potentially activated by tfec in the progenitors of iridophore lineage which is in line with that reported in Petratou et al. 2021. pnp4a is highly expressed in iridophores. As show in this picture : https://dynamo-release.readthedocs.io/en/latest/_images/zebrafish_36_0.png

However,as show in the picture of the result, the color of iridophores part is blue, I think the negative value of Jacobian means pnp4a is supressed by tfec.

Thanks alot.

Fiona

FionaMoon avatar Sep 14 '22 05:09 FionaMoon