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I found that I can configure this sleep timing through the function `set_sleep_timing` to reduce the wait time.
I'm using `PythonIsoTpConnection` in `udsoncan.connections ` to connect the `isotp`.  start up log.  It seems that the code here has done blocking processing. 
I upgraded the new udsoncan library and your implementation was updated,this problem is solved.
> Ah, yes. v1.21+ is required to take advantage of the timing improvements introduced in isotp v2. What version were you using? > > regards v1.13.1, hhh, It's a lot...