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Revise "gene_with_edited_transcript" parentage

Open sjm41 opened this issue 3 years ago • 1 comments

SO term name and accession gene_with_edited_transcript (SO:0000548)

Current parent term name and accession protein_coding_gene (SO:0001217)

Suggested new parent term name and accession gene (SO:0000704)

Reason for the change

  • current def ("A gene that encodes a transcript that is edited.") doesn't specify the gene has to be protein coding
  • Editing sites have been observed in ncRNAs

Relevant Publications PMID: 20382028 ADAR editing in double-stranded UTRs and other noncoding RNA sequences PMID: 28820319 A-to-I RNA editing - thinking beyond the single nucleotide PMID: 28559490 ADAR RNA editing below the backbone

sjm41 avatar Jul 28 '21 13:07 sjm41

@keilbeck Was this term meant to apply to protein coding genes only? It is not specified in the definition, but it can be inferred based on its placement in the ontology. If so, we may want to specify that attribute and create a new term under ncRNA and ncRNA_gene. There are no children of this particular term but the siblings all share a similar format "gene_with_[...]".

egchristensen avatar Nov 11 '21 20:11 egchristensen