RosettaCommons
Guide inpainting
Hello! Awesome code base and docs! I’m trying to inpaint a small domain into a loop that of a TM protein that faces the cytosol. However, I keep getting helices to the TM portion in many of my designs. Is there anyway to use conditioning or another trick to guide the design of inpainting? Or would it mostly be choosing designs that are appropriate and then running partial diffusion?
you could totally set the secondary structure to be a loop in a secondary structure input. You'd just need to make a secondary structure input (loops are value 2), and then set 'scaffoldguided.mask_loops=False'. The default behaviour is to mask loops (for reasons explained in the readme), but you can override this, and it should work (we've done this quite a lot in the lab to make loopy things)
