restore ChEMBL computationally predicted compound-protein edges

Open saramsey opened this issue 4 years ago • 9 comments

Per issue #172, there is a request to restore the computationally predicted compound-to-protein edges (from ChEMBL) in RTX-KG2, that got dropped in KG2.6.0 when we deprecated all the old API-based RTX-KG1 edges.

Nov 04 '21 02:11 saramsey

I am working on figuring out where this is stored in the MySQL dump, since it is stored under "Target Predictions" on each compound's page (ex. https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL112/).

Since the given schema is hard to use, as it is not searchable, I (largely) programmatically generated this file that is a way less pretty version of that file, but is searchable: (ChEMBL 33) searchable_chembl_tables.txt

Jul 11 '23 21:07 ecwood

GitHub's table function is useful for testing queries, so I am going to use it (pardon the volume of comments here)

select * from predicted_binding_domains as pbd inner join activities as act on pbd.activity_id=act.activity_id limit 10;

predbind_id	activity_id	site_id	prediction_method	confidence	activity_id	assay_id	doc_id	record_id	molregno	standard_relation	standard_value	standard_units	standard_flag	standard_type	activity_comment	data_validity_comment	potential_duplicate	pchembl_value	bao_endpoint	uo_units	qudt_units	toid	upper_value	standard_upper_value	src_id	type	relation	value	units	text_value	standard_text_value	action_type
7699241	1451903	1466	Single domain	high	1451903	303582	20206	375261	309144	=	3.700000000000000000000000000000	nM	1	Ki	NULL	NULL	0	8.43	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Ki	=	3.700000000000000000000000000000	nM	NULL	NULL	NULL
7699242	1451927	1133	Single domain	high	1451927	306357	20164	375026	308829	=	5000.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	5.30	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	5000.000000000000000000000000000000	nM	NULL	NULL	NULL
7699243	1452215	1248	Single domain	high	1452215	306777	20159	375678	309524	=	1330.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	5.88	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	1.330000000000000000000000000000	uM	NULL	NULL	NULL
7699244	1452254	1378	Single domain	high	1452254	303155	20185	375103	308824	=	231.000000000000000000000000000000	nM	1	Ki	NULL	NULL	0	6.64	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Ki	=	231.000000000000000000000000000000	nM	NULL	NULL	NULL
7699245	1452283	1415	Single domain	high	1452283	303623	20163	375402	309288	=	170.000000000000000000000000000000	nM	1	Ki	NULL	NULL	0	6.77	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Ki	=	0.170000000000000000000000000000	uM	NULL	NULL	NULL
7699246	1452406	2004	Single domain	high	1452406	305312	20205	375285	309094	=	5.100000000000000000000000000000	nM	1	IC50	NULL	NULL	0	8.29	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	5.100000000000000000000000000000	nM	NULL	NULL	NULL
7699247	1452435	1221	Single domain	high	1452435	305557	20208	375238	309059	=	747.000000000000000000000000000000	nM	1	IC50	NULL	NULL	1	6.13	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	747.000000000000000000000000000000	nM	NULL	NULL	NULL
7699248	1452436	1221	Single domain	high	1452436	305557	20208	375262	309145	=	1450.000000000000000000000000000000	nM	1	IC50	NULL	NULL	1	5.84	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	1450.000000000000000000000000000000	nM	NULL	NULL	NULL
7699249	1452452	115	Single domain	high	1452452	306184	20164	375157	309013	=	17.000000000000000000000000000000	nM	1	IC50	NULL	NULL	1	7.77	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	17.000000000000000000000000000000	nM	NULL	NULL	NULL
7699250	1452530	2302	Single domain	high	1452530	305437	20205	375357	309116	=	48000.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	4.32	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	48.000000000000000000000000000000	uM	NULL	NULL	NULL

select * from predicted_binding_domains as pbd inner join activities as act on pbd.activity_id=act.activity_id inner join chembl_id_lookup as cil on cil.entity_id=act.molregno limit 10;

predbind_id	activity_id	site_id	prediction_method	confidence	activity_id	assay_id	doc_id	record_id	molregno	standard_relation	standard_value	standard_units	standard_flag	standard_type	activity_comment	data_validity_comment	potential_duplicate	pchembl_value	bao_endpoint	uo_units	qudt_units	toid	upper_value	standard_upper_value	src_id	type	relation	value	units	text_value	standard_text_value	action_type	chembl_id	entity_type	entity_id	status	last_active
8375702	2398488	1851	Multi domain	medium	2398488	493332	45880	804813	517180	=	420.000000000000000000000000000000	nM	1	Ki	NULL	NULL	0	6.38	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Ki	=	0.420000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL1	COMPOUND	517180	ACTIVE	33
8068969	468912	1012	Single domain	high	468912	216840	14964	122298	250	=	330.000000000000000000000000000000	nM	1	IC50	NULL	NULL	1	6.48	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	330.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8007410	1449508	1080	Single domain	high	1449508	305440	20173	375696	250	=	136000.000000000000000000000000000000	nM	1	IC50	NULL	Outside typical range	0	NULL	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	136.000000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8470777	1453956	1080	Single domain	high	1453956	305841	20244	376277	250	=	20.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	7.70	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	0.020000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8007523	1454924	1080	Single domain	high	1454924	305835	20245	376210	250	=	10.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	8.00	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	0.010000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
7802766	1474739	1080	Single domain	high	1474739	306037	20573	382108	250	=	72.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	7.14	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	0.072000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
7854170	1474873	1080	Single domain	high	1474873	305015	20573	382108	250	=	48.000000000000000000000000000000	nM	1	IC50	NULL	NULL	1	7.32	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	0.048000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8368073	1512979	3258	Single domain	high	1512979	306685	21295	392429	250	=	16.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	7.80	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	16.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8471231	1512980	2183	Single domain	high	1512980	306220	21295	392429	250	=	135.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	6.87	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	135.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8007949	1512981	1667	Single domain	high	1512981	306129	21295	392429	250	=	124.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	6.91	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	124.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33

select * from predicted_binding_domains as pbd inner join activities as act on pbd.activity_id=act.activity_id inner join chembl_id_lookup as cil on cil.entity_id=act.molregno where cil.chembl_id="CHEMBL10";

predbind_id	activity_id	site_id	prediction_method	confidence	activity_id	assay_id	doc_id	record_id	molregno	standard_relation	standard_value	standard_units	standard_flag	standard_type	activity_comment	data_validity_comment	potential_duplicate	pchembl_value	bao_endpoint	uo_units	qudt_units	toid	upper_value	standard_upper_value	src_id	type	relation	value	units	text_value	standard_text_value	action_type	chembl_id	entity_type	entity_id	status	last_active
8068969	468912	1012	Single domain	high	468912	216840	14964	122298	250	=	330.000000000000000000000000000000	nM	1	IC50	NULL	NULL	1	6.48	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	330.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8007410	1449508	1080	Single domain	high	1449508	305440	20173	375696	250	=	136000.000000000000000000000000000000	nM	1	IC50	NULL	Outside typical range	0	NULL	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	136.000000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8470777	1453956	1080	Single domain	high	1453956	305841	20244	376277	250	=	20.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	7.70	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	0.020000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8007523	1454924	1080	Single domain	high	1454924	305835	20245	376210	250	=	10.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	8.00	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	0.010000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
7802766	1474739	1080	Single domain	high	1474739	306037	20573	382108	250	=	72.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	7.14	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	0.072000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
7854170	1474873	1080	Single domain	high	1474873	305015	20573	382108	250	=	48.000000000000000000000000000000	nM	1	IC50	NULL	NULL	1	7.32	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	0.048000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8368073	1512979	3258	Single domain	high	1512979	306685	21295	392429	250	=	16.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	7.80	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	16.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8471231	1512980	2183	Single domain	high	1512980	306220	21295	392429	250	=	135.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	6.87	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	135.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8007949	1512981	1667	Single domain	high	1512981	306129	21295	392429	250	=	124.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	6.91	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	124.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8111135	1512982	1012	Single domain	high	1512982	305793	21295	392429	250	=	2000.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	5.70	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	2.000000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
7699983	1512983	1515	Single domain	high	1512983	306515	21295	392429	250	=	11000.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	4.96	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	11.000000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
7802998	1512985	1080	Single domain	high	1512985	306493	21295	392429	250	=	38.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	7.42	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	38.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8368074	1512986	1305	Single domain	high	1512986	306478	21295	392429	250	=	500.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	6.30	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	500.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8317845	1651150	303	Single domain	high	1651150	325077	30300	405801	250	=	45.000000000000000000000000000000	nM	1	Kd	NULL	NULL	0	7.35	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	0.045000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
7752823	1651161	2128	Single domain	high	1651161	325013	30300	405801	250	=	860.000000000000000000000000000000	nM	1	Kd	NULL	NULL	0	6.07	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	0.860000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
7957561	1651293	1515	Single domain	high	1651293	325078	30300	405801	250	=	95.000000000000000000000000000000	nM	1	Kd	NULL	NULL	0	7.02	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	0.095000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
7700915	1651392	2105	Single domain	high	1651392	325019	30300	405801	250	=	4600.000000000000000000000000000000	nM	1	Kd	NULL	NULL	0	5.34	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	4.600000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8420855	1651436	3258	Single domain	high	1651436	325052	30300	405801	250	=	2100.000000000000000000000000000000	nM	1	Kd	NULL	NULL	0	5.68	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	2.100000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8266335	1651502	2183	Single domain	high	1651502	325053	30300	405801	250	=	39.000000000000000000000000000000	nM	1	Kd	NULL	NULL	0	7.41	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	0.039000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8420857	1651524	106	Single domain	high	1651524	325105	30300	405801	250	=	2900.000000000000000000000000000000	nM	1	Kd	NULL	NULL	0	5.54	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	2.900000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
7855339	1651601	2106	Single domain	high	1651601	325007	30300	405801	250	=	1500.000000000000000000000000000000	nM	1	Kd	NULL	NULL	0	5.82	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	1.500000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
7855340	1651634	1408	Single domain	high	1651634	325085	30300	405801	250	=	220.000000000000000000000000000000	nM	1	Kd	NULL	NULL	0	6.66	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	0.220000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8214886	1651788	1676	Single domain	high	1651788	325063	30300	405801	250	=	1200.000000000000000000000000000000	nM	1	Kd	NULL	NULL	0	5.92	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	1.200000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
7957569	1651854	1835	Single domain	high	1651854	325056	30300	405801	250	=	1700.000000000000000000000000000000	nM	1	Kd	NULL	NULL	0	5.77	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	1.700000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
7957622	1652041	1305	Single domain	high	1652041	325099	30300	405801	250	=	250.000000000000000000000000000000	nM	1	Kd	NULL	NULL	0	6.60	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	0.250000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8420911	1652052	1080	Single domain	high	1652052	325097	30300	405801	250	=	17.000000000000000000000000000000	nM	1	Kd	NULL	NULL	0	7.77	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	0.017000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
7700473	1658801	1080	Single domain	high	1658801	326792	30400	410874	250	=	290.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	6.54	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	0.290000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8165114	1800072	1080	Single domain	high	1800072	423076	34798	620708	250	=	68.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	7.17	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	0.068000000000000000000000000000	umol/L	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8165261	1820921	1080	Single domain	high	1820921	428526	35192	627121	250	=	30.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	7.52	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	0.030000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8165262	1821058	303	Single domain	high	1821058	428524	35192	627121	250	=	790.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	6.10	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	0.790000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8269593	1838545	1080	Single domain	high	1838545	429743	35279	629833	250	=	462.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	6.33	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	0.462000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8013881	2087654	1080	Single domain	high	2087654	463962	38421	691484	250	=	18.000000000000000000000000000000	nM	1	Ki	NULL	NULL	0	7.75	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Ki	=	18.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8476609	2121297	1080	Single domain	high	2121297	470044	38904	701693	250	=	39.000000000000000000000000000000	nM	1	IC50	NULL	NULL	1	7.41	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	0.039000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
7962119	2121302	1080	Single domain	high	2121302	470045	38904	701693	250	=	6000.000000000000000000000000000000	nM	1	IC50	NULL	NULL	1	5.22	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	6.000000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
7930524	2681438	1080	Single domain	high	2681438	580261	47781	823852	250	=	7000.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	5.16	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	7.000000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8444841	2681439	1179	Multi domain	medium	2681439	580262	47781	823852	250	=	100.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	7.00	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	0.100000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
7931754	2890948	1835	Single domain	high	2890948	586604	48311	845312	250	=	1500.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.82	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	1500.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8188744	2891311	2176	Multi domain	medium	2891311	586360	48311	845312	250	=	250.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	6.60	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	250.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
7726603	2891614	1957	Single domain	high	2891614	587107	48311	845312	250	=	4400.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.36	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	4400.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8034027	2892300	2109	Single domain	high	2892300	586447	48311	845312	250	=	1700.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.77	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	1700.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
7880599	2892338	1667	Single domain	high	2892338	586690	48311	845312	250	=	37.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	7.43	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	37.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
7880601	2892376	1408	Single domain	high	2892376	586816	48311	845312	250	=	100.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	7.00	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	100.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
7880606	2892644	2106	Single domain	high	2892644	586729	48311	845312	250	=	820.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	6.09	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	820.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
7982895	2892834	2152	Single domain	high	2892834	586369	48311	845312	250	=	2500.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.60	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	2500.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
7982951	2893610	1157	Single domain	high	2893610	586329	48311	845312	250	=	1700.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.77	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	1700.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8497657	2894115	1676	Single domain	high	2894115	586332	48311	845312	250	=	1100.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.96	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	1100.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8034097	2894153	1515	Single domain	high	2894153	586575	48311	845312	250	=	130.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	6.89	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	130.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
7726664	2894381	736	Single domain	high	2894381	586335	48311	845312	250	=	9600.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.02	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	9600.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8188818	2895024	2177	Single domain	high	2895024	586833	48311	845312	250	=	25.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	7.60	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	25.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8394727	2895062	1080	Single domain	high	2895062	586347	48311	845312	250	=	12.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	7.92	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	12.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8188820	2895100	1305	Single domain	high	2895100	586717	48311	845312	250	=	70.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	7.16	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	70.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8290720	2895912	303	Single domain	high	2895912	586459	48311	845312	250	=	35.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	7.46	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	35.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
7776923	2896523	1908	Single domain	high	2896523	587064	48311	845312	250	=	3000.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.52	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	3000.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8187806	2896746	2333	Single domain	high	2896746	586366	48311	845312	250	=	3500.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.46	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	3500.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8239371	2896822	2181	Single domain	high	2896822	587221	48311	845312	250	=	2100.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.68	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	2100.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
7776926	2896898	2183	Single domain	high	2896898	586987	48311	845312	250	=	19.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	7.72	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	19.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
7725788	2897530	2463	Single domain	high	2897530	586566	48311	845312	250	=	1000.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	6.00	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	1000.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8033183	2897568	2328	Single domain	high	2897568	586320	48311	845312	250	=	5000.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.30	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	5000.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
7725840	2898610	2332	Single domain	high	2898610	587179	48311	845312	250	=	400.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	6.40	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	400.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8393858	2898686	106	Single domain	high	2898686	586322	48311	845312	250	=	1700.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.77	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	1700.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8342363	2898724	106	Single domain	high	2898724	586957	48311	845312	250	=	340.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	6.47	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	340.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8033246	2898762	106	Single domain	high	2898762	586323	48311	845312	250	=	710.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	6.15	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	710.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8136515	2898800	106	Single domain	high	2898800	586568	48311	845312	250	=	1300.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.89	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	1300.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
7828466	2898838	106	Single domain	high	2898838	586818	48311	845312	250	=	1700.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.77	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	1700.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8085188	2898876	106	Single domain	high	2898876	586819	48311	845312	250	=	1600.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.80	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	1600.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8085189	2898914	106	Single domain	high	2898914	587072	48311	845312	250	=	1500.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.82	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	1500.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8136580	2900076	1172	Single domain	high	2900076	587067	48311	845312	250	=	710.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	6.15	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	710.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
7828526	2900114	1172	Single domain	high	2900114	587068	48311	845312	250	=	530.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	6.28	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	530.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8445461	2900257	1423	Single domain	high	2900257	587076	48311	845312	250	=	3700.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.43	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	3700.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
7931161	2901648	2273	Single domain	high	2901648	587190	48311	845312	250	=	6200.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.21	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	6200.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8290990	2901686	2316	Single domain	high	2901686	587078	48311	845312	250	=	2700.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.57	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	2700.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
7879977	2902285	2037	Single domain	high	2902285	586689	48311	845312	250	=	420.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	6.38	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	420.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8497016	2903900	2105	Single domain	high	2903900	586998	48311	845312	250	=	3700.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.43	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	3700.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
7880046	2904128	2128	Single domain	high	2904128	586728	48311	845312	250	=	1300.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.89	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	1300.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8085405	2904280	919	Single domain	high	2904280	587104	48311	845312	250	=	7100.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.15	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	7100.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
7880051	2904698	106	Single domain	high	2904698	586691	48311	845312	250	=	1900.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.72	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	1900.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
7880053	2904736	106	Single domain	high	2904736	587073	48311	845312	250	=	3200.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.50	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	3200.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8497018	2904774	106	Single domain	high	2904774	586958	48311	845312	250	=	2000.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.70	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	2000.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8394065	2905002	2012	Multi domain	medium	2905002	587181	48311	845312	250	=	1200.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.92	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	1200.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8033455	2905103	3299	Single domain	high	2905103	586859	48311	845312	250	=	1800.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.75	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	1800.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8239742	2906614	1012	Single domain	high	2906614	586722	48311	845312	250	=	980.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	6.01	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	980.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
7931381	2907542	3258	Single domain	high	2907542	587101	48311	845312	250	=	24.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	7.62	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	24.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8497152	2907656	930	Multi domain	medium	2907656	586995	48311	845312	250	=	320.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	6.50	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	320.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
7830202	3117838	1080	Single domain	high	3117838	613377	49743	880368	250	=	48.000000000000000000000000000000	nM	1	IC50	NULL	NULL	1	7.32	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	48.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
7920548	6194531	1080	Single domain	high	6194531	746462	57557	1421198	250	=	15.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	7.82	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	0.015000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8177650	6194532	1080	Single domain	high	6194532	746464	57557	1421198	250	=	1230.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	5.91	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	1.230000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8279989	6282598	1080	Single domain	high	6282598	757551	58265	1439916	250	=	55.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	7.26	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	55.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
7716583	7824300	1688	Single domain	high	7824300	774665	59306	1540140	250	=	11476.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	4.94	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	15	IC50	=	11.476000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8024078	7824358	561	Single domain	high	7824358	774718	59306	1540140	250	=	10553.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	4.98	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	15	IC50	=	10.553000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
7716584	7824359	561	Single domain	high	7824359	774718	59306	1540140	250	=	1759.000000000000000000000000000000	nM	1	Ki	NULL	NULL	0	5.75	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	15	Ki	=	1.759000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8333294	7824376	1660	Multi domain	medium	7824376	774727	59306	1540140	250	=	494.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	6.31	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	15	IC50	=	0.494000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
7820996	12047520	1080	Single domain	high	12047520	852267	65405	1731746	250	=	2000.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	5.70	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	2.000000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8233571	12641807	1080	Single domain	high	12641807	933867	71887	1846630	250	=	273.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	6.56	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	0.273000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8130584	12641827	1080	Single domain	high	12641827	933868	71887	1846630	250	=	48.000000000000000000000000000000	nM	1	IC50	NULL	NULL	1	7.32	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	0.048000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8183379	13321352	1080	Single domain	high	13321352	961834	73740	1895734	250	=	25.000000000000000000000000000000	nM	1	IC50	NULL	NULL	1	7.60	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	25.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8184351	13473783	1755	Single domain	high	13473783	986596	75098	1923305	250	=	37.070000000000000000000000000000	nM	1	IC50	NULL	NULL	0	7.43	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	pIC50	=	7.431000000000000000000000000000	NULL	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
7978544	13827063	1080	Single domain	high	13827063	1275449	75973	1949817	250	=	723.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	6.14	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	0.723000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8390387	13827064	1080	Single domain	high	13827064	1275453	75973	1949817	250	=	48.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	7.32	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	0.048000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8185451	13925323	1080	Single domain	high	13925323	1293611	77014	1968829	250	=	40.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	7.40	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	0.040000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8185462	14525785	1080	Single domain	high	14525785	1332413	81743	2073989	250	=	19.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	7.72	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	0.019000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8082857	14536279	1080	Single domain	high	14536279	1328901	81919	2074210	250	=	35.000000000000000000000000000000	nM	1	IC50	NULL	NULL	1	7.46	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	0.035000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8050834	15250404	2183	Single domain	high	15250404	1478228	91789	2296686	250	=	105.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	6.98	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	105.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8462312	15674357	1212	Single domain	high	15674357	1509067	93036	2492616	250	=	5000.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	5.30	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	5.000000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
7744202	15757720	3258	Single domain	high	15757720	1522562	93770	2507617	250	=	10.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	8.00	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	10.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
7846703	15757721	3258	Single domain	high	15757721	1522561	93770	2507617	250	=	200.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	6.70	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	200.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
7885009	16638298	3258	Single domain	high	16638298	1587102	99693	2785995	250	=	251.190000000000000000000000000000	nM	1	IC50	NULL	NULL	0	6.60	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	pIC50	=	6.600000000000000000000000000000	NULL	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8090397	16638301	3258	Single domain	high	16638301	1587102	99693	2785995	250	=	250.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	6.60	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	250.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
7987248	16638314	3258	Single domain	high	16638314	1587103	99693	2785995	250	=	250.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	6.60	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	250.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8141592	16638318	3258	Single domain	high	16638318	1587104	99693	2785995	250	=	6310.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	5.20	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	6310.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8091854	16844162	1080	Single domain	high	16844162	1634405	102118	2816586	250	=	25.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	7.60	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	25.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8091855	16844164	1305	Single domain	high	16844164	1634406	102118	2816586	250	=	12.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	7.92	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	12.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
7787606	18088790	1080	Single domain	high	18088790	1669515	104693	2999172	250	=	21.700000000000000000000000000000	nM	1	Kd	NULL	NULL	0	7.66	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	21.700000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8043816	18088848	1080	Single domain	high	18088848	1669518	104693	2999172	250	=	2.180000000000000000000000000000	10'-1/s	0	Kd	NULL	NULL	0	NULL	BAO_0000034	NULL	NULL	NULL	NULL	NULL	1	Kd	=	2.180000000000000000000000000000	10'-1/s	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
7747161	18886179	1080	Single domain	high	18886179	1813822	110575	3151310	250	=	60.000000000000000000000000000000	nM	1	EC50	NULL	NULL	0	7.22	BAO_0000188	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	EC50	=	0.060000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8054295	18972896	1080	Single domain	high	18972896	1837206	111210	3164884	250	=	35.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	7.46	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	0.035000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8108719	19225494	1080	Single domain	high	19225494	1893918	113032	3209104	250	=	41.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	7.39	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	41.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
7903119	19225504	1080	Single domain	high	19225504	1893996	113032	3209104	250	=	65.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	7.19	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	65.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
7902867	19291809	865	Single domain	high	19291809	1908922	113505	3221397	250	=	34.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	7.47	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	34.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33
8469311	22929317	1080	Single domain	high	22929317	2082528	119607	3560284	250	=	500.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	6.30	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	0.500000000000000000000000000000	uM	NULL	NULL	INHIBITOR	CHEMBL10	COMPOUND	250	ACTIVE	33

Jul 11 '23 22:07 ecwood

select * from predicted_binding_domains as pbd inner join activities as act on pbd.activity_id=act.activity_id inner join chembl_id_lookup as cil on cil.entity_id=act.molregno inner join binding_sites as bs on pbd.site_id=bs.site_id where cil.chembl_id="CHEMBL10";

predbind_id	activity_id	site_id	prediction_method	confidence	activity_id	assay_id	doc_id	record_id	molregno	standard_relation	standard_value	standard_units	standard_flag	standard_type	activity_comment	data_validity_comment	potential_duplicate	pchembl_value	bao_endpoint	uo_units	qudt_units	toid	upper_value	standard_upper_value	src_id	type	relation	value	units	text_value	standard_text_value	action_type	chembl_id	entity_type	entity_id	status	last_active	site_id	site_name	tid
8068969	468912	1012	Single domain	high	468912	216840	14964	122298	250	=	330.000000000000000000000000000000	nM	1	IC50	NULL	NULL	1	6.48	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	330.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1012	Serine/threonine-protein kinase RAF, Pkinase_Tyr domain	10904
8007410	1449508	1080	Single domain	high	1449508	305440	20173	375696	250	=	136000.000000000000000000000000000000	nM	1	IC50	NULL	Outside typical range	0	NULL	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	136.000000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1080	MAP kinase p38 alpha, Pkinase domain	10188
8470777	1453956	1080	Single domain	high	1453956	305841	20244	376277	250	=	20.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	7.70	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	0.020000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1080	MAP kinase p38 alpha, Pkinase domain	10188
8007523	1454924	1080	Single domain	high	1454924	305835	20245	376210	250	=	10.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	8.00	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	0.010000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1080	MAP kinase p38 alpha, Pkinase domain	10188
7802766	1474739	1080	Single domain	high	1474739	306037	20573	382108	250	=	72.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	7.14	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	0.072000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1080	MAP kinase p38 alpha, Pkinase domain	10188
7854170	1474873	1080	Single domain	high	1474873	305015	20573	382108	250	=	48.000000000000000000000000000000	nM	1	IC50	NULL	NULL	1	7.32	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	0.048000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1080	MAP kinase p38 alpha, Pkinase domain	10188
8368073	1512979	3258	Single domain	high	1512979	306685	21295	392429	250	=	16.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	7.80	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	16.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	3258	Serine/threonine-protein kinase RIPK2, Pkinase_Tyr domain	20025
8471231	1512980	2183	Single domain	high	1512980	306220	21295	392429	250	=	135.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	6.87	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	135.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	2183	Serine/threonine-protein kinase GAK, Pkinase domain	20020
8007949	1512981	1667	Single domain	high	1512981	306129	21295	392429	250	=	124.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	6.91	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	124.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1667	Casein kinase I delta, Pkinase domain	10368
8111135	1512982	1012	Single domain	high	1512982	305793	21295	392429	250	=	2000.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	5.70	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	2.000000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1012	Serine/threonine-protein kinase RAF, Pkinase_Tyr domain	10904
7699983	1512983	1515	Single domain	high	1512983	306515	21295	392429	250	=	11000.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	4.96	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	11.000000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1515	c-Jun N-terminal kinase 2, Pkinase domain	11407
7802998	1512985	1080	Single domain	high	1512985	306493	21295	392429	250	=	38.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	7.42	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	38.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1080	MAP kinase p38 alpha, Pkinase domain	10188
8368074	1512986	1305	Single domain	high	1512986	306478	21295	392429	250	=	500.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	6.30	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	500.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1305	MAP kinase p38 beta, Pkinase domain	10120
8317845	1651150	303	Single domain	high	1651150	325077	30300	405801	250	=	45.000000000000000000000000000000	nM	1	Kd	NULL	NULL	0	7.35	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	0.045000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	303	c-Jun N-terminal kinase 3, Pkinase domain	11408
7752823	1651161	2128	Single domain	high	1651161	325013	30300	405801	250	=	860.000000000000000000000000000000	nM	1	Kd	NULL	NULL	0	6.07	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	0.860000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	2128	Serine/threonine-protein kinase 36, Pkinase domain	30041
7957561	1651293	1515	Single domain	high	1651293	325078	30300	405801	250	=	95.000000000000000000000000000000	nM	1	Kd	NULL	NULL	0	7.02	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	0.095000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1515	c-Jun N-terminal kinase 2, Pkinase domain	11407
7700915	1651392	2105	Single domain	high	1651392	325019	30300	405801	250	=	4600.000000000000000000000000000000	nM	1	Kd	NULL	NULL	0	5.34	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	4.600000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	2105	Serine/threonine-protein kinase 2, Pkinase domain	30035
8420855	1651436	3258	Single domain	high	1651436	325052	30300	405801	250	=	2100.000000000000000000000000000000	nM	1	Kd	NULL	NULL	0	5.68	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	2.100000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	3258	Serine/threonine-protein kinase RIPK2, Pkinase_Tyr domain	20025
8266335	1651502	2183	Single domain	high	1651502	325053	30300	405801	250	=	39.000000000000000000000000000000	nM	1	Kd	NULL	NULL	0	7.41	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	0.039000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	2183	Serine/threonine-protein kinase GAK, Pkinase domain	20020
8420857	1651524	106	Single domain	high	1651524	325105	30300	405801	250	=	2900.000000000000000000000000000000	nM	1	Kd	NULL	NULL	0	5.54	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	2.900000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	106	Epidermal growth factor receptor erbB1, Pkinase_Tyr domain	9
7855339	1651601	2106	Single domain	high	1651601	325007	30300	405801	250	=	1500.000000000000000000000000000000	nM	1	Kd	NULL	NULL	0	5.82	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	1.500000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	2106	TRAF2- and NCK-interacting kinase, Pkinase domain	30047
7855340	1651634	1408	Single domain	high	1651634	325085	30300	405801	250	=	220.000000000000000000000000000000	nM	1	Kd	NULL	NULL	0	6.66	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	0.220000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1408	Casein kinase I epsilon, Pkinase domain	10967
8214886	1651788	1676	Single domain	high	1651788	325063	30300	405801	250	=	1200.000000000000000000000000000000	nM	1	Kd	NULL	NULL	0	5.92	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	1.200000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1676	c-Jun N-terminal kinase 1, Pkinase domain	12261
7957569	1651854	1835	Single domain	high	1651854	325056	30300	405801	250	=	1700.000000000000000000000000000000	nM	1	Kd	NULL	NULL	0	5.77	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	1.700000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1835	MAP kinase p38 gamma, Pkinase domain	12983
7957622	1652041	1305	Single domain	high	1652041	325099	30300	405801	250	=	250.000000000000000000000000000000	nM	1	Kd	NULL	NULL	0	6.60	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	0.250000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1305	MAP kinase p38 beta, Pkinase domain	10120
8420911	1652052	1080	Single domain	high	1652052	325097	30300	405801	250	=	17.000000000000000000000000000000	nM	1	Kd	NULL	NULL	0	7.77	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	0.017000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1080	MAP kinase p38 alpha, Pkinase domain	10188
7700473	1658801	1080	Single domain	high	1658801	326792	30400	410874	250	=	290.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	6.54	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	0.290000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1080	MAP kinase p38 alpha, Pkinase domain	10188
8165114	1800072	1080	Single domain	high	1800072	423076	34798	620708	250	=	68.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	7.17	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	0.068000000000000000000000000000	umol/L	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1080	MAP kinase p38 alpha, Pkinase domain	10188
8165261	1820921	1080	Single domain	high	1820921	428526	35192	627121	250	=	30.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	7.52	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	0.030000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1080	MAP kinase p38 alpha, Pkinase domain	10188
8165262	1821058	303	Single domain	high	1821058	428524	35192	627121	250	=	790.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	6.10	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	0.790000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	303	c-Jun N-terminal kinase 3, Pkinase domain	11408
8269593	1838545	1080	Single domain	high	1838545	429743	35279	629833	250	=	462.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	6.33	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	0.462000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1080	MAP kinase p38 alpha, Pkinase domain	10188
8013881	2087654	1080	Single domain	high	2087654	463962	38421	691484	250	=	18.000000000000000000000000000000	nM	1	Ki	NULL	NULL	0	7.75	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Ki	=	18.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1080	MAP kinase p38 alpha, Pkinase domain	10188
8476609	2121297	1080	Single domain	high	2121297	470044	38904	701693	250	=	39.000000000000000000000000000000	nM	1	IC50	NULL	NULL	1	7.41	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	0.039000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1080	MAP kinase p38 alpha, Pkinase domain	10188
7962119	2121302	1080	Single domain	high	2121302	470045	38904	701693	250	=	6000.000000000000000000000000000000	nM	1	IC50	NULL	NULL	1	5.22	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	6.000000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1080	MAP kinase p38 alpha, Pkinase domain	10188
7930524	2681438	1080	Single domain	high	2681438	580261	47781	823852	250	=	7000.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	5.16	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	7.000000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1080	MAP kinase p38 alpha, Pkinase domain	10188
8444841	2681439	1179	Multi domain	medium	2681439	580262	47781	823852	250	=	100.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	7.00	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	0.100000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1179	Mitogen-activated protein kinase 1, Pkinase domain	102397
7931754	2890948	1835	Single domain	high	2890948	586604	48311	845312	250	=	1500.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.82	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	1500.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1835	MAP kinase p38 gamma, Pkinase domain	12983
8188744	2891311	2176	Multi domain	medium	2891311	586360	48311	845312	250	=	250.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	6.60	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	250.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	2176	Ribosomal protein S6 kinase alpha 6, Pkinase domain	10939
7726603	2891614	1957	Single domain	high	2891614	587107	48311	845312	250	=	4400.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.36	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	4400.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1957	Mixed lineage kinase 7, Pkinase_Tyr domain	20007
8034027	2892300	2109	Single domain	high	2892300	586447	48311	845312	250	=	1700.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.77	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	1700.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	2109	Casein kinase I isoform alpha-like, Pkinase domain	101222
7880599	2892338	1667	Single domain	high	2892338	586690	48311	845312	250	=	37.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	7.43	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	37.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1667	Casein kinase I delta, Pkinase domain	10368
7880601	2892376	1408	Single domain	high	2892376	586816	48311	845312	250	=	100.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	7.00	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	100.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1408	Casein kinase I epsilon, Pkinase domain	10967
7880606	2892644	2106	Single domain	high	2892644	586729	48311	845312	250	=	820.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	6.09	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	820.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	2106	TRAF2- and NCK-interacting kinase, Pkinase domain	30047
7982895	2892834	2152	Single domain	high	2892834	586369	48311	845312	250	=	2500.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.60	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	2500.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	2152	Dual specificity protein kinase TTK, Pkinase domain	30011
7982951	2893610	1157	Single domain	high	2893610	586329	48311	845312	250	=	1700.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.77	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	1700.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1157	Glycogen synthase kinase-3 beta, Pkinase domain	10197
8497657	2894115	1676	Single domain	high	2894115	586332	48311	845312	250	=	1100.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.96	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	1100.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1676	c-Jun N-terminal kinase 1, Pkinase domain	12261
8034097	2894153	1515	Single domain	high	2894153	586575	48311	845312	250	=	130.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	6.89	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	130.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1515	c-Jun N-terminal kinase 2, Pkinase domain	11407
7726664	2894381	736	Single domain	high	2894381	586335	48311	845312	250	=	9600.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.02	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	9600.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	736	Dual specificity mitogen-activated protein kinase kinase 2, Pkinase domain	11046
8188818	2895024	2177	Single domain	high	2895024	586833	48311	845312	250	=	25.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	7.60	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	25.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	2177	Serine/threonine protein kinase NLK, Pkinase domain	100931
8394727	2895062	1080	Single domain	high	2895062	586347	48311	845312	250	=	12.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	7.92	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	12.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1080	MAP kinase p38 alpha, Pkinase domain	10188
8188820	2895100	1305	Single domain	high	2895100	586717	48311	845312	250	=	70.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	7.16	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	70.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1305	MAP kinase p38 beta, Pkinase domain	10120
8290720	2895912	303	Single domain	high	2895912	586459	48311	845312	250	=	35.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	7.46	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	35.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	303	c-Jun N-terminal kinase 3, Pkinase domain	11408
7776923	2896523	1908	Single domain	high	2896523	587064	48311	845312	250	=	3000.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.52	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	3000.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1908	Activin receptor type-1B, Pkinase domain	100908
8187806	2896746	2333	Single domain	high	2896746	586366	48311	845312	250	=	3500.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.46	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	3500.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	2333	Serine/threonine-protein kinase TNNI3K, Pkinase_Tyr domain	101130
8239371	2896822	2181	Single domain	high	2896822	587221	48311	845312	250	=	2100.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.68	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	2100.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	2181	Serine/threonine-protein kinase 32B, Pkinase domain	101607
7776926	2896898	2183	Single domain	high	2896898	586987	48311	845312	250	=	19.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	7.72	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	19.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	2183	Serine/threonine-protein kinase GAK, Pkinase domain	20020
7725788	2897530	2463	Single domain	high	2897530	586566	48311	845312	250	=	1000.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	6.00	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	1000.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	2463	Epithelial discoidin domain-containing receptor 1, Pkinase_Tyr domain	100917
8033183	2897568	2328	Single domain	high	2897568	586320	48311	845312	250	=	5000.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.30	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	5000.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	2328	Discoidin domain-containing receptor 2, Pkinase_Tyr domain	101079
7725840	2898610	2332	Single domain	high	2898610	587179	48311	845312	250	=	400.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	6.40	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	400.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	2332	Serine/threonine-protein kinase MRCK gamma, Pkinase domain	101041
8393858	2898686	106	Single domain	high	2898686	586322	48311	845312	250	=	1700.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.77	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	1700.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	106	Epidermal growth factor receptor erbB1, Pkinase_Tyr domain	9
8342363	2898724	106	Single domain	high	2898724	586957	48311	845312	250	=	340.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	6.47	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	340.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	106	Epidermal growth factor receptor erbB1, Pkinase_Tyr domain	9
8033246	2898762	106	Single domain	high	2898762	586323	48311	845312	250	=	710.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	6.15	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	710.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	106	Epidermal growth factor receptor erbB1, Pkinase_Tyr domain	9
8136515	2898800	106	Single domain	high	2898800	586568	48311	845312	250	=	1300.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.89	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	1300.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	106	Epidermal growth factor receptor erbB1, Pkinase_Tyr domain	9
7828466	2898838	106	Single domain	high	2898838	586818	48311	845312	250	=	1700.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.77	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	1700.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	106	Epidermal growth factor receptor erbB1, Pkinase_Tyr domain	9
8085188	2898876	106	Single domain	high	2898876	586819	48311	845312	250	=	1600.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.80	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	1600.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	106	Epidermal growth factor receptor erbB1, Pkinase_Tyr domain	9
8085189	2898914	106	Single domain	high	2898914	587072	48311	845312	250	=	1500.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.82	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	1500.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	106	Epidermal growth factor receptor erbB1, Pkinase_Tyr domain	9
8136580	2900076	1172	Single domain	high	2900076	587067	48311	845312	250	=	710.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	6.15	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	710.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1172	Serine/threonine-protein kinase B-raf, Pkinase_Tyr domain	100126
7828526	2900114	1172	Single domain	high	2900114	587068	48311	845312	250	=	530.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	6.28	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	530.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1172	Serine/threonine-protein kinase B-raf, Pkinase_Tyr domain	100126
8445461	2900257	1423	Single domain	high	2900257	587076	48311	845312	250	=	3700.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.43	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	3700.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1423	Mitogen-activated protein kinase kinase kinase kinase 4, Pkinase domain	101464
7931161	2901648	2273	Single domain	high	2901648	587190	48311	845312	250	=	6200.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.21	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	6200.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	2273	Serine/threonine-protein kinase MRCK-A, Pkinase domain	100845
8290990	2901686	2316	Single domain	high	2901686	587078	48311	845312	250	=	2700.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.57	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	2700.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	2316	Serine/threonine-protein kinase MRCK beta, Pkinase domain	101053
7879977	2902285	2037	Single domain	high	2902285	586689	48311	845312	250	=	420.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	6.38	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	420.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	2037	Citron Rho-interacting kinase, Pkinase domain	101239
8497016	2903900	2105	Single domain	high	2903900	586998	48311	845312	250	=	3700.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.43	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	3700.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	2105	Serine/threonine-protein kinase 2, Pkinase domain	30035
7880046	2904128	2128	Single domain	high	2904128	586728	48311	845312	250	=	1300.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.89	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	1300.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	2128	Serine/threonine-protein kinase 36, Pkinase domain	30041
8085405	2904280	919	Single domain	high	2904280	587104	48311	845312	250	=	7100.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.15	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	7100.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	919	TGF-beta receptor type I, Pkinase domain	13004
7880051	2904698	106	Single domain	high	2904698	586691	48311	845312	250	=	1900.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.72	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	1900.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	106	Epidermal growth factor receptor erbB1, Pkinase_Tyr domain	9
7880053	2904736	106	Single domain	high	2904736	587073	48311	845312	250	=	3200.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.50	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	3200.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	106	Epidermal growth factor receptor erbB1, Pkinase_Tyr domain	9
8497018	2904774	106	Single domain	high	2904774	586958	48311	845312	250	=	2000.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.70	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	2000.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	106	Epidermal growth factor receptor erbB1, Pkinase_Tyr domain	9
8394065	2905002	2012	Multi domain	medium	2905002	587181	48311	845312	250	=	1200.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.92	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	1200.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	2012	Ephrin type-A receptor 6, Pkinase_Tyr domain	30046
8033455	2905103	3299	Single domain	high	2905103	586859	48311	845312	250	=	1800.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.75	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	1800.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	3299	TGF-beta receptor type II, Pkinase_Tyr domain	100075
8239742	2906614	1012	Single domain	high	2906614	586722	48311	845312	250	=	980.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	6.01	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	980.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1012	Serine/threonine-protein kinase RAF, Pkinase_Tyr domain	10904
7931381	2907542	3258	Single domain	high	2907542	587101	48311	845312	250	=	24.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	7.62	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	24.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	3258	Serine/threonine-protein kinase RIPK2, Pkinase_Tyr domain	20025
8497152	2907656	930	Multi domain	medium	2907656	586995	48311	845312	250	=	320.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	6.50	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	320.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	930	Ribosomal protein S6 kinase alpha 1, Pkinase domain	10929
7830202	3117838	1080	Single domain	high	3117838	613377	49743	880368	250	=	48.000000000000000000000000000000	nM	1	IC50	NULL	NULL	1	7.32	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	48.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1080	MAP kinase p38 alpha, Pkinase domain	10188
7920548	6194531	1080	Single domain	high	6194531	746462	57557	1421198	250	=	15.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	7.82	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	0.015000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1080	MAP kinase p38 alpha, Pkinase domain	10188
8177650	6194532	1080	Single domain	high	6194532	746464	57557	1421198	250	=	1230.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	5.91	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	1.230000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1080	MAP kinase p38 alpha, Pkinase domain	10188
8279989	6282598	1080	Single domain	high	6282598	757551	58265	1439916	250	=	55.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	7.26	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	55.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1080	MAP kinase p38 alpha, Pkinase domain	10188
7716583	7824300	1688	Single domain	high	7824300	774665	59306	1540140	250	=	11476.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	4.94	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	15	IC50	=	11.476000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1688	Phosphodiesterase 5A, PDEase_I domain	3
8024078	7824358	561	Single domain	high	7824358	774718	59306	1540140	250	=	10553.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	4.98	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	15	IC50	=	10.553000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	561	Serotonin 4 (5-HT4) receptor, 7tm_1 domain	20033
7716584	7824359	561	Single domain	high	7824359	774718	59306	1540140	250	=	1759.000000000000000000000000000000	nM	1	Ki	NULL	NULL	0	5.75	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	15	Ki	=	1.759000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	561	Serotonin 4 (5-HT4) receptor, 7tm_1 domain	20033
8333294	7824376	1660	Multi domain	medium	7824376	774727	59306	1540140	250	=	494.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	6.31	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	15	IC50	=	0.494000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1660	Thromboxane-A synthase, p450 domain	248
7820996	12047520	1080	Single domain	high	12047520	852267	65405	1731746	250	=	2000.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	5.70	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	2.000000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1080	MAP kinase p38 alpha, Pkinase domain	10188
8233571	12641807	1080	Single domain	high	12641807	933867	71887	1846630	250	=	273.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	6.56	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	0.273000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1080	MAP kinase p38 alpha, Pkinase domain	10188
8130584	12641827	1080	Single domain	high	12641827	933868	71887	1846630	250	=	48.000000000000000000000000000000	nM	1	IC50	NULL	NULL	1	7.32	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	0.048000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1080	MAP kinase p38 alpha, Pkinase domain	10188
8183379	13321352	1080	Single domain	high	13321352	961834	73740	1895734	250	=	25.000000000000000000000000000000	nM	1	IC50	NULL	NULL	1	7.60	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	25.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1080	MAP kinase p38 alpha, Pkinase domain	10188
8184351	13473783	1755	Single domain	high	13473783	986596	75098	1923305	250	=	37.070000000000000000000000000000	nM	1	IC50	NULL	NULL	0	7.43	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	pIC50	=	7.431000000000000000000000000000	NULL	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1755	Glucagon receptor, 7tm_2 domain	146
7978544	13827063	1080	Single domain	high	13827063	1275449	75973	1949817	250	=	723.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	6.14	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	0.723000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1080	MAP kinase p38 alpha, Pkinase domain	10188
8390387	13827064	1080	Single domain	high	13827064	1275453	75973	1949817	250	=	48.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	7.32	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	0.048000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1080	MAP kinase p38 alpha, Pkinase domain	10188
8185451	13925323	1080	Single domain	high	13925323	1293611	77014	1968829	250	=	40.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	7.40	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	0.040000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1080	MAP kinase p38 alpha, Pkinase domain	10188
8185462	14525785	1080	Single domain	high	14525785	1332413	81743	2073989	250	=	19.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	7.72	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	0.019000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1080	MAP kinase p38 alpha, Pkinase domain	10188
8082857	14536279	1080	Single domain	high	14536279	1328901	81919	2074210	250	=	35.000000000000000000000000000000	nM	1	IC50	NULL	NULL	1	7.46	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	0.035000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1080	MAP kinase p38 alpha, Pkinase domain	10188
8050834	15250404	2183	Single domain	high	15250404	1478228	91789	2296686	250	=	105.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	6.98	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	105.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	2183	Serine/threonine-protein kinase GAK, Pkinase domain	20020
8462312	15674357	1212	Single domain	high	15674357	1509067	93036	2492616	250	=	5000.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	5.30	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	5.000000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1212	P2X purinoceptor 7, P2X_receptor domain	10417
7744202	15757720	3258	Single domain	high	15757720	1522562	93770	2507617	250	=	10.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	8.00	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	10.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	3258	Serine/threonine-protein kinase RIPK2, Pkinase_Tyr domain	20025
7846703	15757721	3258	Single domain	high	15757721	1522561	93770	2507617	250	=	200.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	6.70	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	200.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	3258	Serine/threonine-protein kinase RIPK2, Pkinase_Tyr domain	20025
7885009	16638298	3258	Single domain	high	16638298	1587102	99693	2785995	250	=	251.190000000000000000000000000000	nM	1	IC50	NULL	NULL	0	6.60	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	pIC50	=	6.600000000000000000000000000000	NULL	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	3258	Serine/threonine-protein kinase RIPK2, Pkinase_Tyr domain	20025
8090397	16638301	3258	Single domain	high	16638301	1587102	99693	2785995	250	=	250.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	6.60	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	250.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	3258	Serine/threonine-protein kinase RIPK2, Pkinase_Tyr domain	20025
7987248	16638314	3258	Single domain	high	16638314	1587103	99693	2785995	250	=	250.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	6.60	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	250.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	3258	Serine/threonine-protein kinase RIPK2, Pkinase_Tyr domain	20025
8141592	16638318	3258	Single domain	high	16638318	1587104	99693	2785995	250	=	6310.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	5.20	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	6310.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	3258	Serine/threonine-protein kinase RIPK2, Pkinase_Tyr domain	20025
8091854	16844162	1080	Single domain	high	16844162	1634405	102118	2816586	250	=	25.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	7.60	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	25.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1080	MAP kinase p38 alpha, Pkinase domain	10188
8091855	16844164	1305	Single domain	high	16844164	1634406	102118	2816586	250	=	12.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	7.92	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	12.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1305	MAP kinase p38 beta, Pkinase domain	10120
7787606	18088790	1080	Single domain	high	18088790	1669515	104693	2999172	250	=	21.700000000000000000000000000000	nM	1	Kd	NULL	NULL	0	7.66	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	21.700000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1080	MAP kinase p38 alpha, Pkinase domain	10188
8043816	18088848	1080	Single domain	high	18088848	1669518	104693	2999172	250	=	2.180000000000000000000000000000	10'-1/s	0	Kd	NULL	NULL	0	NULL	BAO_0000034	NULL	NULL	NULL	NULL	NULL	1	Kd	=	2.180000000000000000000000000000	10'-1/s	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1080	MAP kinase p38 alpha, Pkinase domain	10188
7747161	18886179	1080	Single domain	high	18886179	1813822	110575	3151310	250	=	60.000000000000000000000000000000	nM	1	EC50	NULL	NULL	0	7.22	BAO_0000188	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	EC50	=	0.060000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1080	MAP kinase p38 alpha, Pkinase domain	10188
8054295	18972896	1080	Single domain	high	18972896	1837206	111210	3164884	250	=	35.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	7.46	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	0.035000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1080	MAP kinase p38 alpha, Pkinase domain	10188
8108719	19225494	1080	Single domain	high	19225494	1893918	113032	3209104	250	=	41.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	7.39	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	41.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1080	MAP kinase p38 alpha, Pkinase domain	10188
7903119	19225504	1080	Single domain	high	19225504	1893996	113032	3209104	250	=	65.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	7.19	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	65.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1080	MAP kinase p38 alpha, Pkinase domain	10188
7902867	19291809	865	Single domain	high	19291809	1908922	113505	3221397	250	=	34.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	7.47	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	34.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	865	Tyrosinase, Tyrosinase domain	101158
8469311	22929317	1080	Single domain	high	22929317	2082528	119607	3560284	250	=	500.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	6.30	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	0.500000000000000000000000000000	uM	NULL	NULL	INHIBITOR	CHEMBL10	COMPOUND	250	ACTIVE	33	1080	MAP kinase p38 alpha, Pkinase domain	10188

Jul 11 '23 22:07 ecwood

This query is pretty promising but also returns a lot of documents and inactive or empty targets:

select * from predicted_binding_domains as pbd inner join activities as act on pbd.activity_id=act.activity_id inner join chembl_id_lookup as cil on cil.entity_id=act.molregno inner join binding_sites as bs on pbd.site_id=bs.site_id inner join chembl_id_lookup as cil2 on cil2.entity_id=bs.tid;

For CHEMBL.COMPOUND:CHEMBL10, when only counting distinct cil.chembl_id matches, there are 2 "TISSUE" matches, 4 "CELL" matches, 38 "DOCUMENT" matches, 44 "ASSAY" matches, 44 "COMPOUND" matches, and 44 "TARGET" matches.

select cil2.chembl_id, group_concat(distinct cil2.entity_type) from predicted_binding_domains as pbd inner join activities as act on pbd.activity_id=act.activity_id inner join chembl_id_lookup as cil on cil.entity_id=act.molregno inner join binding_sites as bs on pbd.site_id=bs.site_id inner join chembl_id_lookup as cil2 on cil2.entity_id=bs.tid where cil.chembl_id="CHEMBL10" group by cil2.chembl_id;

Here's the target results only:

ChEMBL ID	Type	On https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL10/?
CHEMBL1827	TARGET	No
CHEMBL1835	TARGET	Yes
CHEMBL1906	TARGET	No
CHEMBL1985	TARGET	No
CHEMBL203	TARGET	No
CHEMBL2276	TARGET	No
CHEMBL2553	TARGET	No
CHEMBL260	TARGET	No
CHEMBL262	TARGET	No
CHEMBL2637	TARGET	No
CHEMBL2828	TARGET	No
CHEMBL2964	TARGET	No
CHEMBL3886	TARGET	No
CHEMBL3961	TARGET	No
CHEMBL3983	TARGET	No
CHEMBL4179	TARGET	No
CHEMBL4202	TARGET	No
CHEMBL4267	TARGET	No
CHEMBL4312	TARGET	No
CHEMBL4355	TARGET	No
CHEMBL4439	TARGET	No
CHEMBL4516	TARGET	No
CHEMBL4526	TARGET	No
CHEMBL4527	TARGET	No
CHEMBL4674	TARGET	No
CHEMBL4805	TARGET	No
CHEMBL4924	TARGET	No
CHEMBL4937	TARGET	No
CHEMBL5014	TARGET	No
CHEMBL5017	TARGET	No
CHEMBL5052	TARGET	No
CHEMBL5122	TARGET	No
CHEMBL5145	TARGET	Yes
CHEMBL5260	TARGET	No
CHEMBL5310	TARGET	No
CHEMBL5319	TARGET	No
CHEMBL5346	TARGET	No
CHEMBL5364	TARGET	No
CHEMBL5520	TARGET	No
CHEMBL5579	TARGET	No
CHEMBL5615	TARGET	No
CHEMBL5912	TARGET	No
CHEMBL6051	TARGET	No
CHEMBL6166	TARGET	No

Jul 11 '23 23:07 ecwood

If we constrain the entity type to "TARGET", we get the same number of rows, because chembl_id_lookup duplicates ID's for each type.

select * from predicted_binding_domains as pbd inner join activities as act on pbd.activity_id=act.activity_id inner join chembl_id_lookup as cil on cil.entity_id=act.molregno inner join binding_sites as bs on pbd.site_id=bs.site_id inner join chembl_id_lookup as cil2 on cil2.entity_id=bs.tid where cil.chembl_id="CHEMBL10" and cil2.entity_type="TARGET";

predbind_id	activity_id	site_id	prediction_method	confidence	activity_id	assay_id	doc_id	record_id	molregno	standard_relation	standard_value	standard_units	standard_flag	standard_type	activity_comment	data_validity_comment	potential_duplicate	pchembl_value	bao_endpoint	uo_units	qudt_units	toid	upper_value	standard_upper_value	src_id	type	relation	value	units	text_value	standard_text_value	action_type	chembl_id	entity_type	entity_id	status	last_active	site_id	site_name	tid	chembl_id	entity_type	entity_id	status	last_active
8068969	468912	1012	Single domain	high	468912	216840	14964	122298	250	=	330.000000000000000000000000000000	nM	1	IC50	NULL	NULL	1	6.48	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	330.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1012	Serine/threonine-protein kinase RAF, Pkinase_Tyr domain	10904	CHEMBL1906	TARGET	10904	ACTIVE	33
8007410	1449508	1080	Single domain	high	1449508	305440	20173	375696	250	=	136000.000000000000000000000000000000	nM	1	IC50	NULL	Outside typical range	0	NULL	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	136.000000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1080	MAP kinase p38 alpha, Pkinase domain	10188	CHEMBL260	TARGET	10188	ACTIVE	33
8470777	1453956	1080	Single domain	high	1453956	305841	20244	376277	250	=	20.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	7.70	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	0.020000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1080	MAP kinase p38 alpha, Pkinase domain	10188	CHEMBL260	TARGET	10188	ACTIVE	33
8007523	1454924	1080	Single domain	high	1454924	305835	20245	376210	250	=	10.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	8.00	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	0.010000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1080	MAP kinase p38 alpha, Pkinase domain	10188	CHEMBL260	TARGET	10188	ACTIVE	33
7802766	1474739	1080	Single domain	high	1474739	306037	20573	382108	250	=	72.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	7.14	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	0.072000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1080	MAP kinase p38 alpha, Pkinase domain	10188	CHEMBL260	TARGET	10188	ACTIVE	33
7854170	1474873	1080	Single domain	high	1474873	305015	20573	382108	250	=	48.000000000000000000000000000000	nM	1	IC50	NULL	NULL	1	7.32	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	0.048000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1080	MAP kinase p38 alpha, Pkinase domain	10188	CHEMBL260	TARGET	10188	ACTIVE	33
8368073	1512979	3258	Single domain	high	1512979	306685	21295	392429	250	=	16.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	7.80	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	16.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	3258	Serine/threonine-protein kinase RIPK2, Pkinase_Tyr domain	20025	CHEMBL5014	TARGET	20025	ACTIVE	33
8471231	1512980	2183	Single domain	high	1512980	306220	21295	392429	250	=	135.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	6.87	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	135.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	2183	Serine/threonine-protein kinase GAK, Pkinase domain	20020	CHEMBL4355	TARGET	20020	ACTIVE	33
8007949	1512981	1667	Single domain	high	1512981	306129	21295	392429	250	=	124.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	6.91	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	124.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1667	Casein kinase I delta, Pkinase domain	10368	CHEMBL2828	TARGET	10368	ACTIVE	33
8111135	1512982	1012	Single domain	high	1512982	305793	21295	392429	250	=	2000.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	5.70	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	2.000000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1012	Serine/threonine-protein kinase RAF, Pkinase_Tyr domain	10904	CHEMBL1906	TARGET	10904	ACTIVE	33
7699983	1512983	1515	Single domain	high	1512983	306515	21295	392429	250	=	11000.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	4.96	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	11.000000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1515	c-Jun N-terminal kinase 2, Pkinase domain	11407	CHEMBL4179	TARGET	11407	ACTIVE	33
7802998	1512985	1080	Single domain	high	1512985	306493	21295	392429	250	=	38.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	7.42	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	38.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1080	MAP kinase p38 alpha, Pkinase domain	10188	CHEMBL260	TARGET	10188	ACTIVE	33
8368074	1512986	1305	Single domain	high	1512986	306478	21295	392429	250	=	500.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	6.30	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	500.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1305	MAP kinase p38 beta, Pkinase domain	10120	CHEMBL3961	TARGET	10120	ACTIVE	33
8317845	1651150	303	Single domain	high	1651150	325077	30300	405801	250	=	45.000000000000000000000000000000	nM	1	Kd	NULL	NULL	0	7.35	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	0.045000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	303	c-Jun N-terminal kinase 3, Pkinase domain	11408	CHEMBL2637	TARGET	11408	ACTIVE	33
7752823	1651161	2128	Single domain	high	1651161	325013	30300	405801	250	=	860.000000000000000000000000000000	nM	1	Kd	NULL	NULL	0	6.07	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	0.860000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	2128	Serine/threonine-protein kinase 36, Pkinase domain	30041	CHEMBL4312	TARGET	30041	ACTIVE	33
7957561	1651293	1515	Single domain	high	1651293	325078	30300	405801	250	=	95.000000000000000000000000000000	nM	1	Kd	NULL	NULL	0	7.02	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	0.095000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1515	c-Jun N-terminal kinase 2, Pkinase domain	11407	CHEMBL4179	TARGET	11407	ACTIVE	33
7700915	1651392	2105	Single domain	high	1651392	325019	30300	405801	250	=	4600.000000000000000000000000000000	nM	1	Kd	NULL	NULL	0	5.34	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	4.600000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	2105	Serine/threonine-protein kinase 2, Pkinase domain	30035	CHEMBL4202	TARGET	30035	ACTIVE	33
8420855	1651436	3258	Single domain	high	1651436	325052	30300	405801	250	=	2100.000000000000000000000000000000	nM	1	Kd	NULL	NULL	0	5.68	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	2.100000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	3258	Serine/threonine-protein kinase RIPK2, Pkinase_Tyr domain	20025	CHEMBL5014	TARGET	20025	ACTIVE	33
8266335	1651502	2183	Single domain	high	1651502	325053	30300	405801	250	=	39.000000000000000000000000000000	nM	1	Kd	NULL	NULL	0	7.41	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	0.039000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	2183	Serine/threonine-protein kinase GAK, Pkinase domain	20020	CHEMBL4355	TARGET	20020	ACTIVE	33
8420857	1651524	106	Single domain	high	1651524	325105	30300	405801	250	=	2900.000000000000000000000000000000	nM	1	Kd	NULL	NULL	0	5.54	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	2.900000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	106	Epidermal growth factor receptor erbB1, Pkinase_Tyr domain	9	CHEMBL203	TARGET	9	ACTIVE	33
7855339	1651601	2106	Single domain	high	1651601	325007	30300	405801	250	=	1500.000000000000000000000000000000	nM	1	Kd	NULL	NULL	0	5.82	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	1.500000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	2106	TRAF2- and NCK-interacting kinase, Pkinase domain	30047	CHEMBL4527	TARGET	30047	ACTIVE	33
7855340	1651634	1408	Single domain	high	1651634	325085	30300	405801	250	=	220.000000000000000000000000000000	nM	1	Kd	NULL	NULL	0	6.66	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	0.220000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1408	Casein kinase I epsilon, Pkinase domain	10967	CHEMBL4937	TARGET	10967	ACTIVE	33
8214886	1651788	1676	Single domain	high	1651788	325063	30300	405801	250	=	1200.000000000000000000000000000000	nM	1	Kd	NULL	NULL	0	5.92	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	1.200000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1676	c-Jun N-terminal kinase 1, Pkinase domain	12261	CHEMBL2276	TARGET	12261	ACTIVE	33
7957569	1651854	1835	Single domain	high	1651854	325056	30300	405801	250	=	1700.000000000000000000000000000000	nM	1	Kd	NULL	NULL	0	5.77	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	1.700000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1835	MAP kinase p38 gamma, Pkinase domain	12983	CHEMBL4674	TARGET	12983	ACTIVE	33
7957622	1652041	1305	Single domain	high	1652041	325099	30300	405801	250	=	250.000000000000000000000000000000	nM	1	Kd	NULL	NULL	0	6.60	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	0.250000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1305	MAP kinase p38 beta, Pkinase domain	10120	CHEMBL3961	TARGET	10120	ACTIVE	33
8420911	1652052	1080	Single domain	high	1652052	325097	30300	405801	250	=	17.000000000000000000000000000000	nM	1	Kd	NULL	NULL	0	7.77	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	0.017000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1080	MAP kinase p38 alpha, Pkinase domain	10188	CHEMBL260	TARGET	10188	ACTIVE	33
7700473	1658801	1080	Single domain	high	1658801	326792	30400	410874	250	=	290.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	6.54	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	0.290000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1080	MAP kinase p38 alpha, Pkinase domain	10188	CHEMBL260	TARGET	10188	ACTIVE	33
8165114	1800072	1080	Single domain	high	1800072	423076	34798	620708	250	=	68.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	7.17	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	0.068000000000000000000000000000	umol/L	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1080	MAP kinase p38 alpha, Pkinase domain	10188	CHEMBL260	TARGET	10188	ACTIVE	33
8165261	1820921	1080	Single domain	high	1820921	428526	35192	627121	250	=	30.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	7.52	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	0.030000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1080	MAP kinase p38 alpha, Pkinase domain	10188	CHEMBL260	TARGET	10188	ACTIVE	33
8165262	1821058	303	Single domain	high	1821058	428524	35192	627121	250	=	790.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	6.10	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	0.790000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	303	c-Jun N-terminal kinase 3, Pkinase domain	11408	CHEMBL2637	TARGET	11408	ACTIVE	33
8269593	1838545	1080	Single domain	high	1838545	429743	35279	629833	250	=	462.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	6.33	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	0.462000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1080	MAP kinase p38 alpha, Pkinase domain	10188	CHEMBL260	TARGET	10188	ACTIVE	33
8013881	2087654	1080	Single domain	high	2087654	463962	38421	691484	250	=	18.000000000000000000000000000000	nM	1	Ki	NULL	NULL	0	7.75	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Ki	=	18.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1080	MAP kinase p38 alpha, Pkinase domain	10188	CHEMBL260	TARGET	10188	ACTIVE	33
8476609	2121297	1080	Single domain	high	2121297	470044	38904	701693	250	=	39.000000000000000000000000000000	nM	1	IC50	NULL	NULL	1	7.41	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	0.039000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1080	MAP kinase p38 alpha, Pkinase domain	10188	CHEMBL260	TARGET	10188	ACTIVE	33
7962119	2121302	1080	Single domain	high	2121302	470045	38904	701693	250	=	6000.000000000000000000000000000000	nM	1	IC50	NULL	NULL	1	5.22	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	6.000000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1080	MAP kinase p38 alpha, Pkinase domain	10188	CHEMBL260	TARGET	10188	ACTIVE	33
7930524	2681438	1080	Single domain	high	2681438	580261	47781	823852	250	=	7000.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	5.16	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	7.000000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1080	MAP kinase p38 alpha, Pkinase domain	10188	CHEMBL260	TARGET	10188	ACTIVE	33
8444841	2681439	1179	Multi domain	medium	2681439	580262	47781	823852	250	=	100.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	7.00	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	0.100000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1179	Mitogen-activated protein kinase 1, Pkinase domain	102397	CHEMBL6051	TARGET	102397	ACTIVE	33
7931754	2890948	1835	Single domain	high	2890948	586604	48311	845312	250	=	1500.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.82	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	1500.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1835	MAP kinase p38 gamma, Pkinase domain	12983	CHEMBL4674	TARGET	12983	ACTIVE	33
8188744	2891311	2176	Multi domain	medium	2891311	586360	48311	845312	250	=	250.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	6.60	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	250.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	2176	Ribosomal protein S6 kinase alpha 6, Pkinase domain	10939	CHEMBL4924	TARGET	10939	ACTIVE	33
7726603	2891614	1957	Single domain	high	2891614	587107	48311	845312	250	=	4400.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.36	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	4400.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1957	Mixed lineage kinase 7, Pkinase_Tyr domain	20007	CHEMBL3886	TARGET	20007	ACTIVE	33
8034027	2892300	2109	Single domain	high	2892300	586447	48311	845312	250	=	1700.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.77	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	1700.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	2109	Casein kinase I isoform alpha-like, Pkinase domain	101222	CHEMBL5520	TARGET	101222	ACTIVE	33
7880599	2892338	1667	Single domain	high	2892338	586690	48311	845312	250	=	37.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	7.43	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	37.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1667	Casein kinase I delta, Pkinase domain	10368	CHEMBL2828	TARGET	10368	ACTIVE	33
7880601	2892376	1408	Single domain	high	2892376	586816	48311	845312	250	=	100.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	7.00	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	100.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1408	Casein kinase I epsilon, Pkinase domain	10967	CHEMBL4937	TARGET	10967	ACTIVE	33
7880606	2892644	2106	Single domain	high	2892644	586729	48311	845312	250	=	820.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	6.09	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	820.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	2106	TRAF2- and NCK-interacting kinase, Pkinase domain	30047	CHEMBL4527	TARGET	30047	ACTIVE	33
7982895	2892834	2152	Single domain	high	2892834	586369	48311	845312	250	=	2500.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.60	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	2500.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	2152	Dual specificity protein kinase TTK, Pkinase domain	30011	CHEMBL3983	TARGET	30011	ACTIVE	33
7982951	2893610	1157	Single domain	high	2893610	586329	48311	845312	250	=	1700.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.77	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	1700.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1157	Glycogen synthase kinase-3 beta, Pkinase domain	10197	CHEMBL262	TARGET	10197	ACTIVE	33
8497657	2894115	1676	Single domain	high	2894115	586332	48311	845312	250	=	1100.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.96	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	1100.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1676	c-Jun N-terminal kinase 1, Pkinase domain	12261	CHEMBL2276	TARGET	12261	ACTIVE	33
8034097	2894153	1515	Single domain	high	2894153	586575	48311	845312	250	=	130.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	6.89	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	130.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1515	c-Jun N-terminal kinase 2, Pkinase domain	11407	CHEMBL4179	TARGET	11407	ACTIVE	33
7726664	2894381	736	Single domain	high	2894381	586335	48311	845312	250	=	9600.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.02	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	9600.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	736	Dual specificity mitogen-activated protein kinase kinase 2, Pkinase domain	11046	CHEMBL2964	TARGET	11046	ACTIVE	33
8188818	2895024	2177	Single domain	high	2895024	586833	48311	845312	250	=	25.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	7.60	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	25.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	2177	Serine/threonine protein kinase NLK, Pkinase domain	100931	CHEMBL5364	TARGET	100931	ACTIVE	33
8394727	2895062	1080	Single domain	high	2895062	586347	48311	845312	250	=	12.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	7.92	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	12.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1080	MAP kinase p38 alpha, Pkinase domain	10188	CHEMBL260	TARGET	10188	ACTIVE	33
8188820	2895100	1305	Single domain	high	2895100	586717	48311	845312	250	=	70.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	7.16	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	70.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1305	MAP kinase p38 beta, Pkinase domain	10120	CHEMBL3961	TARGET	10120	ACTIVE	33
8290720	2895912	303	Single domain	high	2895912	586459	48311	845312	250	=	35.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	7.46	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	35.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	303	c-Jun N-terminal kinase 3, Pkinase domain	11408	CHEMBL2637	TARGET	11408	ACTIVE	33
7776923	2896523	1908	Single domain	high	2896523	587064	48311	845312	250	=	3000.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.52	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	3000.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1908	Activin receptor type-1B, Pkinase domain	100908	CHEMBL5310	TARGET	100908	ACTIVE	33
8187806	2896746	2333	Single domain	high	2896746	586366	48311	845312	250	=	3500.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.46	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	3500.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	2333	Serine/threonine-protein kinase TNNI3K, Pkinase_Tyr domain	101130	CHEMBL5260	TARGET	101130	ACTIVE	33
8239371	2896822	2181	Single domain	high	2896822	587221	48311	845312	250	=	2100.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.68	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	2100.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	2181	Serine/threonine-protein kinase 32B, Pkinase domain	101607	CHEMBL5912	TARGET	101607	ACTIVE	33
7776926	2896898	2183	Single domain	high	2896898	586987	48311	845312	250	=	19.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	7.72	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	19.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	2183	Serine/threonine-protein kinase GAK, Pkinase domain	20020	CHEMBL4355	TARGET	20020	ACTIVE	33
7725788	2897530	2463	Single domain	high	2897530	586566	48311	845312	250	=	1000.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	6.00	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	1000.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	2463	Epithelial discoidin domain-containing receptor 1, Pkinase_Tyr domain	100917	CHEMBL5319	TARGET	100917	ACTIVE	33
8033183	2897568	2328	Single domain	high	2897568	586320	48311	845312	250	=	5000.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.30	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	5000.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	2328	Discoidin domain-containing receptor 2, Pkinase_Tyr domain	101079	CHEMBL5122	TARGET	101079	ACTIVE	33
7725840	2898610	2332	Single domain	high	2898610	587179	48311	845312	250	=	400.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	6.40	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	400.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	2332	Serine/threonine-protein kinase MRCK gamma, Pkinase domain	101041	CHEMBL5615	TARGET	101041	ACTIVE	33
8393858	2898686	106	Single domain	high	2898686	586322	48311	845312	250	=	1700.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.77	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	1700.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	106	Epidermal growth factor receptor erbB1, Pkinase_Tyr domain	9	CHEMBL203	TARGET	9	ACTIVE	33
8342363	2898724	106	Single domain	high	2898724	586957	48311	845312	250	=	340.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	6.47	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	340.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	106	Epidermal growth factor receptor erbB1, Pkinase_Tyr domain	9	CHEMBL203	TARGET	9	ACTIVE	33
8033246	2898762	106	Single domain	high	2898762	586323	48311	845312	250	=	710.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	6.15	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	710.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	106	Epidermal growth factor receptor erbB1, Pkinase_Tyr domain	9	CHEMBL203	TARGET	9	ACTIVE	33
8136515	2898800	106	Single domain	high	2898800	586568	48311	845312	250	=	1300.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.89	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	1300.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	106	Epidermal growth factor receptor erbB1, Pkinase_Tyr domain	9	CHEMBL203	TARGET	9	ACTIVE	33
7828466	2898838	106	Single domain	high	2898838	586818	48311	845312	250	=	1700.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.77	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	1700.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	106	Epidermal growth factor receptor erbB1, Pkinase_Tyr domain	9	CHEMBL203	TARGET	9	ACTIVE	33
8085188	2898876	106	Single domain	high	2898876	586819	48311	845312	250	=	1600.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.80	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	1600.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	106	Epidermal growth factor receptor erbB1, Pkinase_Tyr domain	9	CHEMBL203	TARGET	9	ACTIVE	33
8085189	2898914	106	Single domain	high	2898914	587072	48311	845312	250	=	1500.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.82	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	1500.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	106	Epidermal growth factor receptor erbB1, Pkinase_Tyr domain	9	CHEMBL203	TARGET	9	ACTIVE	33
8136580	2900076	1172	Single domain	high	2900076	587067	48311	845312	250	=	710.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	6.15	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	710.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1172	Serine/threonine-protein kinase B-raf, Pkinase_Tyr domain	100126	CHEMBL5145	TARGET	100126	ACTIVE	33
7828526	2900114	1172	Single domain	high	2900114	587068	48311	845312	250	=	530.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	6.28	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	530.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1172	Serine/threonine-protein kinase B-raf, Pkinase_Tyr domain	100126	CHEMBL5145	TARGET	100126	ACTIVE	33
8445461	2900257	1423	Single domain	high	2900257	587076	48311	845312	250	=	3700.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.43	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	3700.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1423	Mitogen-activated protein kinase kinase kinase kinase 4, Pkinase domain	101464	CHEMBL6166	TARGET	101464	ACTIVE	33
7931161	2901648	2273	Single domain	high	2901648	587190	48311	845312	250	=	6200.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.21	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	6200.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	2273	Serine/threonine-protein kinase MRCK-A, Pkinase domain	100845	CHEMBL4516	TARGET	100845	ACTIVE	33
8290990	2901686	2316	Single domain	high	2901686	587078	48311	845312	250	=	2700.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.57	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	2700.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	2316	Serine/threonine-protein kinase MRCK beta, Pkinase domain	101053	CHEMBL5052	TARGET	101053	ACTIVE	33
7879977	2902285	2037	Single domain	high	2902285	586689	48311	845312	250	=	420.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	6.38	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	420.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	2037	Citron Rho-interacting kinase, Pkinase domain	101239	CHEMBL5579	TARGET	101239	ACTIVE	33
8497016	2903900	2105	Single domain	high	2903900	586998	48311	845312	250	=	3700.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.43	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	3700.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	2105	Serine/threonine-protein kinase 2, Pkinase domain	30035	CHEMBL4202	TARGET	30035	ACTIVE	33
7880046	2904128	2128	Single domain	high	2904128	586728	48311	845312	250	=	1300.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.89	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	1300.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	2128	Serine/threonine-protein kinase 36, Pkinase domain	30041	CHEMBL4312	TARGET	30041	ACTIVE	33
8085405	2904280	919	Single domain	high	2904280	587104	48311	845312	250	=	7100.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.15	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	7100.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	919	TGF-beta receptor type I, Pkinase domain	13004	CHEMBL4439	TARGET	13004	ACTIVE	33
7880051	2904698	106	Single domain	high	2904698	586691	48311	845312	250	=	1900.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.72	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	1900.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	106	Epidermal growth factor receptor erbB1, Pkinase_Tyr domain	9	CHEMBL203	TARGET	9	ACTIVE	33
7880053	2904736	106	Single domain	high	2904736	587073	48311	845312	250	=	3200.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.50	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	3200.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	106	Epidermal growth factor receptor erbB1, Pkinase_Tyr domain	9	CHEMBL203	TARGET	9	ACTIVE	33
8497018	2904774	106	Single domain	high	2904774	586958	48311	845312	250	=	2000.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.70	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	2000.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	106	Epidermal growth factor receptor erbB1, Pkinase_Tyr domain	9	CHEMBL203	TARGET	9	ACTIVE	33
8394065	2905002	2012	Multi domain	medium	2905002	587181	48311	845312	250	=	1200.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.92	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	1200.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	2012	Ephrin type-A receptor 6, Pkinase_Tyr domain	30046	CHEMBL4526	TARGET	30046	ACTIVE	33
8033455	2905103	3299	Single domain	high	2905103	586859	48311	845312	250	=	1800.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	5.75	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	1800.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	3299	TGF-beta receptor type II, Pkinase_Tyr domain	100075	CHEMBL4267	TARGET	100075	ACTIVE	33
8239742	2906614	1012	Single domain	high	2906614	586722	48311	845312	250	=	980.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	6.01	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	980.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1012	Serine/threonine-protein kinase RAF, Pkinase_Tyr domain	10904	CHEMBL1906	TARGET	10904	ACTIVE	33
7931381	2907542	3258	Single domain	high	2907542	587101	48311	845312	250	=	24.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	7.62	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	24.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	3258	Serine/threonine-protein kinase RIPK2, Pkinase_Tyr domain	20025	CHEMBL5014	TARGET	20025	ACTIVE	33
8497152	2907656	930	Multi domain	medium	2907656	586995	48311	845312	250	=	320.000000000000000000000000000000	nM	1	Kd	NULL	NULL	1	6.50	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	320.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	930	Ribosomal protein S6 kinase alpha 1, Pkinase domain	10929	CHEMBL2553	TARGET	10929	ACTIVE	33
7830202	3117838	1080	Single domain	high	3117838	613377	49743	880368	250	=	48.000000000000000000000000000000	nM	1	IC50	NULL	NULL	1	7.32	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	48.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1080	MAP kinase p38 alpha, Pkinase domain	10188	CHEMBL260	TARGET	10188	ACTIVE	33
7920548	6194531	1080	Single domain	high	6194531	746462	57557	1421198	250	=	15.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	7.82	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	0.015000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1080	MAP kinase p38 alpha, Pkinase domain	10188	CHEMBL260	TARGET	10188	ACTIVE	33
8177650	6194532	1080	Single domain	high	6194532	746464	57557	1421198	250	=	1230.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	5.91	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	1.230000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1080	MAP kinase p38 alpha, Pkinase domain	10188	CHEMBL260	TARGET	10188	ACTIVE	33
8279989	6282598	1080	Single domain	high	6282598	757551	58265	1439916	250	=	55.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	7.26	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	55.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1080	MAP kinase p38 alpha, Pkinase domain	10188	CHEMBL260	TARGET	10188	ACTIVE	33
7716583	7824300	1688	Single domain	high	7824300	774665	59306	1540140	250	=	11476.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	4.94	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	15	IC50	=	11.476000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1688	Phosphodiesterase 5A, PDEase_I domain	3	CHEMBL1827	TARGET	3	ACTIVE	33
8024078	7824358	561	Single domain	high	7824358	774718	59306	1540140	250	=	10553.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	4.98	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	15	IC50	=	10.553000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	561	Serotonin 4 (5-HT4) receptor, 7tm_1 domain	20033	CHEMBL5017	TARGET	20033	ACTIVE	33
7716584	7824359	561	Single domain	high	7824359	774718	59306	1540140	250	=	1759.000000000000000000000000000000	nM	1	Ki	NULL	NULL	0	5.75	BAO_0000192	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	15	Ki	=	1.759000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	561	Serotonin 4 (5-HT4) receptor, 7tm_1 domain	20033	CHEMBL5017	TARGET	20033	ACTIVE	33
8333294	7824376	1660	Multi domain	medium	7824376	774727	59306	1540140	250	=	494.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	6.31	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	15	IC50	=	0.494000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1660	Thromboxane-A synthase, p450 domain	248	CHEMBL1835	TARGET	248	ACTIVE	33
7820996	12047520	1080	Single domain	high	12047520	852267	65405	1731746	250	=	2000.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	5.70	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	2.000000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1080	MAP kinase p38 alpha, Pkinase domain	10188	CHEMBL260	TARGET	10188	ACTIVE	33
8233571	12641807	1080	Single domain	high	12641807	933867	71887	1846630	250	=	273.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	6.56	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	0.273000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1080	MAP kinase p38 alpha, Pkinase domain	10188	CHEMBL260	TARGET	10188	ACTIVE	33
8130584	12641827	1080	Single domain	high	12641827	933868	71887	1846630	250	=	48.000000000000000000000000000000	nM	1	IC50	NULL	NULL	1	7.32	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	0.048000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1080	MAP kinase p38 alpha, Pkinase domain	10188	CHEMBL260	TARGET	10188	ACTIVE	33
8183379	13321352	1080	Single domain	high	13321352	961834	73740	1895734	250	=	25.000000000000000000000000000000	nM	1	IC50	NULL	NULL	1	7.60	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	25.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1080	MAP kinase p38 alpha, Pkinase domain	10188	CHEMBL260	TARGET	10188	ACTIVE	33
8184351	13473783	1755	Single domain	high	13473783	986596	75098	1923305	250	=	37.070000000000000000000000000000	nM	1	IC50	NULL	NULL	0	7.43	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	pIC50	=	7.431000000000000000000000000000	NULL	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1755	Glucagon receptor, 7tm_2 domain	146	CHEMBL1985	TARGET	146	ACTIVE	33
7978544	13827063	1080	Single domain	high	13827063	1275449	75973	1949817	250	=	723.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	6.14	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	0.723000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1080	MAP kinase p38 alpha, Pkinase domain	10188	CHEMBL260	TARGET	10188	ACTIVE	33
8390387	13827064	1080	Single domain	high	13827064	1275453	75973	1949817	250	=	48.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	7.32	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	0.048000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1080	MAP kinase p38 alpha, Pkinase domain	10188	CHEMBL260	TARGET	10188	ACTIVE	33
8185451	13925323	1080	Single domain	high	13925323	1293611	77014	1968829	250	=	40.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	7.40	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	0.040000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1080	MAP kinase p38 alpha, Pkinase domain	10188	CHEMBL260	TARGET	10188	ACTIVE	33
8185462	14525785	1080	Single domain	high	14525785	1332413	81743	2073989	250	=	19.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	7.72	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	0.019000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1080	MAP kinase p38 alpha, Pkinase domain	10188	CHEMBL260	TARGET	10188	ACTIVE	33
8082857	14536279	1080	Single domain	high	14536279	1328901	81919	2074210	250	=	35.000000000000000000000000000000	nM	1	IC50	NULL	NULL	1	7.46	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	0.035000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1080	MAP kinase p38 alpha, Pkinase domain	10188	CHEMBL260	TARGET	10188	ACTIVE	33
8050834	15250404	2183	Single domain	high	15250404	1478228	91789	2296686	250	=	105.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	6.98	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	105.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	2183	Serine/threonine-protein kinase GAK, Pkinase domain	20020	CHEMBL4355	TARGET	20020	ACTIVE	33
8462312	15674357	1212	Single domain	high	15674357	1509067	93036	2492616	250	=	5000.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	5.30	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	5.000000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1212	P2X purinoceptor 7, P2X_receptor domain	10417	CHEMBL4805	TARGET	10417	ACTIVE	33
7744202	15757720	3258	Single domain	high	15757720	1522562	93770	2507617	250	=	10.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	8.00	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	10.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	3258	Serine/threonine-protein kinase RIPK2, Pkinase_Tyr domain	20025	CHEMBL5014	TARGET	20025	ACTIVE	33
7846703	15757721	3258	Single domain	high	15757721	1522561	93770	2507617	250	=	200.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	6.70	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	200.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	3258	Serine/threonine-protein kinase RIPK2, Pkinase_Tyr domain	20025	CHEMBL5014	TARGET	20025	ACTIVE	33
7885009	16638298	3258	Single domain	high	16638298	1587102	99693	2785995	250	=	251.190000000000000000000000000000	nM	1	IC50	NULL	NULL	0	6.60	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	pIC50	=	6.600000000000000000000000000000	NULL	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	3258	Serine/threonine-protein kinase RIPK2, Pkinase_Tyr domain	20025	CHEMBL5014	TARGET	20025	ACTIVE	33
8090397	16638301	3258	Single domain	high	16638301	1587102	99693	2785995	250	=	250.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	6.60	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	250.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	3258	Serine/threonine-protein kinase RIPK2, Pkinase_Tyr domain	20025	CHEMBL5014	TARGET	20025	ACTIVE	33
7987248	16638314	3258	Single domain	high	16638314	1587103	99693	2785995	250	=	250.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	6.60	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	250.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	3258	Serine/threonine-protein kinase RIPK2, Pkinase_Tyr domain	20025	CHEMBL5014	TARGET	20025	ACTIVE	33
8141592	16638318	3258	Single domain	high	16638318	1587104	99693	2785995	250	=	6310.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	5.20	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	6310.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	3258	Serine/threonine-protein kinase RIPK2, Pkinase_Tyr domain	20025	CHEMBL5014	TARGET	20025	ACTIVE	33
8091854	16844162	1080	Single domain	high	16844162	1634405	102118	2816586	250	=	25.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	7.60	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	25.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1080	MAP kinase p38 alpha, Pkinase domain	10188	CHEMBL260	TARGET	10188	ACTIVE	33
8091855	16844164	1305	Single domain	high	16844164	1634406	102118	2816586	250	=	12.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	7.92	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	12.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1305	MAP kinase p38 beta, Pkinase domain	10120	CHEMBL3961	TARGET	10120	ACTIVE	33
7787606	18088790	1080	Single domain	high	18088790	1669515	104693	2999172	250	=	21.700000000000000000000000000000	nM	1	Kd	NULL	NULL	0	7.66	BAO_0000034	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	Kd	=	21.700000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1080	MAP kinase p38 alpha, Pkinase domain	10188	CHEMBL260	TARGET	10188	ACTIVE	33
8043816	18088848	1080	Single domain	high	18088848	1669518	104693	2999172	250	=	2.180000000000000000000000000000	10'-1/s	0	Kd	NULL	NULL	0	NULL	BAO_0000034	NULL	NULL	NULL	NULL	NULL	1	Kd	=	2.180000000000000000000000000000	10'-1/s	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1080	MAP kinase p38 alpha, Pkinase domain	10188	CHEMBL260	TARGET	10188	ACTIVE	33
7747161	18886179	1080	Single domain	high	18886179	1813822	110575	3151310	250	=	60.000000000000000000000000000000	nM	1	EC50	NULL	NULL	0	7.22	BAO_0000188	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	EC50	=	0.060000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1080	MAP kinase p38 alpha, Pkinase domain	10188	CHEMBL260	TARGET	10188	ACTIVE	33
8054295	18972896	1080	Single domain	high	18972896	1837206	111210	3164884	250	=	35.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	7.46	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	0.035000000000000000000000000000	uM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1080	MAP kinase p38 alpha, Pkinase domain	10188	CHEMBL260	TARGET	10188	ACTIVE	33
8108719	19225494	1080	Single domain	high	19225494	1893918	113032	3209104	250	=	41.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	7.39	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	41.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1080	MAP kinase p38 alpha, Pkinase domain	10188	CHEMBL260	TARGET	10188	ACTIVE	33
7903119	19225504	1080	Single domain	high	19225504	1893996	113032	3209104	250	=	65.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	7.19	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	65.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	1080	MAP kinase p38 alpha, Pkinase domain	10188	CHEMBL260	TARGET	10188	ACTIVE	33
7902867	19291809	865	Single domain	high	19291809	1908922	113505	3221397	250	=	34.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	7.47	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	34.000000000000000000000000000000	nM	NULL	NULL	NULL	CHEMBL10	COMPOUND	250	ACTIVE	33	865	Tyrosinase, Tyrosinase domain	101158	CHEMBL5346	TARGET	101158	ACTIVE	33
8469311	22929317	1080	Single domain	high	22929317	2082528	119607	3560284	250	=	500.000000000000000000000000000000	nM	1	IC50	NULL	NULL	0	6.30	BAO_0000190	UO_0000065	http://www.openphacts.org/units/Nanomolar	NULL	NULL	NULL	1	IC50	=	0.500000000000000000000000000000	uM	NULL	NULL	INHIBITOR	CHEMBL10	COMPOUND	250	ACTIVE	33	1080	MAP kinase p38 alpha, Pkinase domain	10188	CHEMBL260	TARGET	10188	ACTIVE	33

Jul 12 '23 16:07 ecwood

After spending a while looking through the MySQL database, I decided to reach out to the ChEMBL help desk:

I am working on ETLing ChEMBL's "Target Prediction" (that's the label on the compound pages, such https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL10/) information to RTX-KG2 using ChEMBL's MySQL dump, version 33. I noticed there is a table for binding site predictions, but I don't see one for target predictions. Is this stored somewhere in the ChEMBL MySQL download? If not, is there another way I can download it?

I got a response today:

Thanks for your message. More information can be found in this Blog post - https://chembl.blogspot.com/2020/01/new-chembl-ligand-based-target.html. Target predictions can be found on the interface and predictions can be run using the Docker image. Hopefully this helps but please get back in touch if you have further questions.

Jul 14 '23 16:07 ecwood

It was a good idea to contact the ChEMBL helpdesk. However, it sounds like they might be saying that the predictions are not in their SQL dump?

Jul 17 '23 21:07 saramsey

That is definitely what they are saying with this. It would be a lot of work to bring in the predictions through a Docker image. I'm not sure if it is worth it or not.

Jul 17 '23 21:07 ecwood

OK, I'm going to change this to "low priority". Maybe we will get to it in the future. Thank you for researching it.

Aug 21 '23 23:08 saramsey