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Potential useful information to review and add to the readthedocs page - from learning unit 9
Peptides FDRs do not correspond to protein FDRs. Currently, large-scale studies often have dozens or hundreds of LC-MS runs that are being accumulated. Repeated measurements lead to an accumulation of false positive identifications. As a rule of thumb, protein FDR increases linearly with the number of repeat measurements. Then an existing solution is to estimate FDR in the same fashion as peptides FDRs through a target-decoy approach, which is called MAYU (no acronym).