Open-Systems-Pharmacology
Opening V11 PK-Sim project in PK-Sim and sending a simulation to MoBi does not properly work
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Open the Midazolam project from here https://github.com/Open-Systems-Pharmacology/OSP-PBPK-Model-Library/tree/master/Midazolam in PK-Sim 12
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Send the simulation "iv 0.05 mg/kg (2 min)" to MoBi
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Create a new simulation from the existing building blocs
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Try to run the simulation:
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Compare simulations: there are tons of differences. How can this be?
E.g. Organism|Volume (plasma) is defined as a sum formula in the building block but not in the simulation! Where are expression values stored?
No, there are just many parameters that are in the simulation and not in the building blocks. E.g. "Weight" is not defined etc..
After recent work for other issues related to ontogeny parameters, those seem to be cleared up but BMI remains
Parameter Rate Definition Organism-BMI has calculation method "Individual_HeightDependent"
But is not contained in the Individual OriginData calculation method cache
If I create a new individual, then the CalculationMethod is part of the OriginData and export/import works.
This must be another project conversion step that needs to be implemented
The same principal is used in the BSA formula that's shown in the screenshot. Follow both to find the difference
Individual_HeightDependent
Parameter Rate Definition Organism-BMI has calculation method "Individual_HeightDependent"
But is not contained in the Individual OriginData calculation method cache
If I create a new individual, then the CalculationMethod is part of the OriginData and export/import works.
This must be another project conversion step that needs to be implemented
thanks
