MR_BACOn
MR_BACOn copied to clipboard
NCBI-Hackathons
Mendelian Randomization with Biomarker Associations for Causality with Outcomes
Either A) I grab a selection of diseases or B) grab the gwas catalog as a whole but I think I'll start small for proof of concept
Constraints: we need to have snps overlapped and pruned in advance. If there's a faster way of doing it that would be great but unknown.
Doable but the time it takes goes from minutes to days? So we need to have an option where the user can decide if they want to do that step...
Network of analysis of related metabolites that are in the same pathway as the metabolite of interest.
Give the user the option to input their own disease gwas data into the app. We need to specify the required column names
Give the user the ability to select which causal effect method to use. * Currently: ** TwoSampleMR * Future: ** MRPC (https://www.biorxiv.org/content/early/2017/08/01/171348) ** Other Causal effect methods
For the pathway analysis, we plan to: 1. Identify the kegg pathways in which a metabolite is involved. 2. For each pathway, run TwoSampleMR for each component metabolite. 3. For...
Metadata
Owner
Metadata
Mendelian Randomization with Biomarker Associations for Causality with Outcomes