IsoCor
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Question on the parameter "correct_NA_tracer"
I recently encountered IsoCor and it fits my need so well! However, I am confused about the parameter correct_NA_tracer in the function isocor.mscorrectors.LowResMetaboliteCorrector. Suppose I want to correct the observed MID of mz 233 in the mass spectrum of malic acid (3TMS). The fragment formula is C9H21O3Si2. The formula of the metabolite moiety is C3H3O3 and the formula of the derivative moiety is C6H18Si2. According to the IsoCor tutorial, I used the following code
corrector_LR = isocor.mscorrectors.LowResMetaboliteCorrector( formula='C3H3O3', # elemental formula of the metabolite moiety tracer="13C", derivative_formula='C6H18Si2', # elemental formula of the derivative moiety tracer_purity=[0.0, 1.0], data_isotopes=isocor.mscorrectors.LowResMetaboliteCorrector.DEFAULT_ISODATA, correct_NA_tracer=False/True )
Here is my question. If I want to correct the observed MID, shall I set correct_NA_tracer to True or False? What does this parameter do exactly?