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JonJala
std_betas and perfect_gencov
I am running MTAG with multiple measures of the same traits. GWAS are from the same samples. I used beta and se as input. It seems that I cannot call std_betas and perfect_gencov simultaneously.
I wonder why this is the case? And in when is std_betas recommended?
Thank you
Honestly, I'm not sure why a person would want to use the std-betas option. MTAG by default uses Z-statistics to do its analysis, which means the results are in standardized units, which are then transformed into allele count units before they are returned. That option just skips the last step. We included it just for the flexibility.
On Sat, Jul 4, 2020 at 2:49 PM jianhuang [email protected] wrote:
I am running MTAG with multiple measures of the same traits. GWAS are from the same samples. I used beta and se as input. It seems that I cannot call std_betas and perfect_gencov simultaneously.
I wonder why this is the case? And in when is std_betas recommended?
Thank you
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