Questions about the effect size inflation of MTAG

[test12138jooh]

Dear professor， We conducted an analysis using MTAG. Overall, the correlation between the effect sizes from MTAG and the original GWAS is quite good, r=0.67; however, we found that the effect sizes of some loci have changed significantly. The previous explanation was that the effect sizes estimated by MTAG were within the confidence intervals of the original GWAS estimates. https://github.com/JonJala/mtag/issues/209

However, we have found that many loci do not meet this criterion. Here are some examples.

RAW phenotype1 GWAS summary：beta=-0.05；SE=0.01616；P=0.001324 MTAG phenotype1 summary：beta=-0.12；SE=0011；P=2.04E-25

Thanks again.

Best, JOOH