HOL
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irule_at any should work on universally quantifier conjuncts.
Here is a small example.
Theorem test:
(!a c. A ==> B a c) ==>
(!c. B a c) /\ C /\ D
Proof
works
DISCH_TAC
CONJ_TAC
pop_assum (irule_at Any)
fails
disch_then (irule_at Any)