ANCOM_BC2's Global test approach?

[aimirza]

What is ANCOM-BC2's approach for determining taxa that are globally different between 3 or more groups? Dunnett's test is not a global test; rather, it is a post-hoc test used in statistics after carrying out a global test such as ANOVA. The purpose of a global test, like ANOVA, is to determine if there are any significant differences among group means. However, it does not specify where these differences lie. Dunnett's test comes into play after you have found significant differences with a global test (like ANOVA). It is specifically designed to compare multiple treatment groups to a single control group, making it useful in situations where you have one control and several experimental conditions. This test helps in identifying which specific groups differ from the control group. How does ANCOM-BC2 determine features that are signficantly different globally?

[Maggie8888]

Please refer to the link for ANCOMBC2 https://bioconductor.org/packages/release/bioc/vignettes/ANCOMBC/inst/doc/ANCOMBC2.html and the link below for details in terms of the methods https://www.nature.com/articles/s41467-020-17041-7