Bismark Alignment very slow

[Nitin123-4]

Hi Team,

I am running Bismark with the below command. I can see it's really slow.

bismark --bowtie2 -N 1 --parallel 4 $RESOURCES2/HG38/ -1 $Read1 -2 $Read2 --output_dir $PWD --temp_dir $PWD/$SAMPLEID"_TEMP" --prefix $SAMPLEID

I have 218,289,382 total reads i.e. 32.96(Gb) data. I did pre processing using Trimmomatic. Filtered reads are used for this. It took ~22 h to complete. Can you please help with this?

Bismark Version: v0.24.0