Danko-Lab
Whether I can use single nuclei RNA-seq data as input
I am wondering whether I can use single nuclei RNA-seq data as input. Compared with scRNA-seq, snRNA-seq tends to capture the mRNA inside the nuclei. I think this might introduce some potential biases.
Yes. When using scNUC-seq as the input, please use the updated cell type fraction as the batch effect is often very strong.
On Thu, Sep 1, 2022 at 5:11 PM Dexin @.***> wrote:
I am wondering whether I can use single nuclei RNA-seq data as input. Compared with scRNA-seq, snRNA-seq tends to capture the mRNA inside the nuclei. I think this might introduce some potential biases.
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