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[Bug] DNAscope gnomad rule failing due to memory

Open mathiasbio opened this issue 1 year ago • 0 comments
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Description

A couple of WGS cases have now been unable to complete in the DNAscope gnomad rule which creates a BAF file to be used as input in GENS. See deviation: https://github.com/Clinical-Genomics/Deviations/issues/631

The memory issues seem to appear after entry into the HLA-region in chromosome 6, with a warning like this: 2024-05-07/05:43:07.323620 HCAssembler WARN :skip selectHaplotype 6:32492321-32492798 due to big read number 44 and big hap number 34117160

But it's strange that the cases keep increasing memory even after it has finished processing this region, and that it's so sample dependent, where these problematic samples can't finish even with 400G mem, whereas other samples finish entirely without having used more than around 30G.

How to reproduce

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Expected behaviour

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Anything else?

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Pipeline version

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mathiasbio avatar May 07 '24 14:05 mathiasbio