Christoph Hafemeister comments

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                                            Christoph Hafemeister

DP simulated data has inverted logFC and only one bimodal group

Short recap: 1. Genes generated under the DP model show unexpected logFC (observed logFC is almost always opposite direction of the logFC of the gene_info table in the simulation metadata)...

Which `selection.method` to use for FindingVariableFeatures on ALRA imputed data

I'd stick to the raw counts (not imputed) and use the `vst` method. If there is no mean-variance relationship, the data is violating some basic assumptions the method is based...