A problem with installing and running the package

[mohame793]

I tried to install the package in R studio it gave me this error message BiocManager::install("BioinformaticsFMRP/TCGAbiolinks") Bioconductor version 3.11 (BiocManager 1.30.10), R 4.0.1 (2020-06-06) Installing package(s) 'BiocVersion' Warning: unable to access index for repository https://cran.rstudio.com/src/contrib: cannot open URL 'https://cran.rstudio.com/src/contrib/PACKAGES' Warning: unable to access index for repository https://cran.rstudio.com/bin/windows/contrib/4.0: cannot open URL 'https://cran.rstudio.com/bin/windows/contrib/4.0/PACKAGES' trying URL 'https://bioconductor.org/packages/3.11/bioc/bin/windows/contrib/4.0/BiocVersion_3.11.1.zip' Content type 'application/zip' length 8904 bytes downloaded 8904 bytes

package ‘BiocVersion’ successfully unpacked and MD5 sums checked

The downloaded binary packages are in C:\Users\M.Elshaer\AppData\Local\Temp\RtmpkPGqb0\downloaded_packages Installing github package(s) 'BioinformaticsFMRP/TCGAbiolinks' Error: package 'remotes' not installed in library path(s) C:/Users/M.Elshaer/Documents/R/win-library/4.0 C:/Program Files/R/R-4.0.1/library install with 'install("remotes")' In addition: Warning message: In file(con, "r") : InternetOpenUrl failed: '‎bn' #so i tried to install it in R version 4.0.1 it seems like it was successfully installed, However, when I tried to read files it gave this message. Error in TCGAquery(tumor = c("LGG", "GBM"), level = 3, platform = c("HumanMethylation450", : could not find function "TCGAquery"

also, i tried this

query.exp <- GDCquery(

• project = "TCGA-BRCA",
• legacy = FALSE,
• data.category = "Transcriptome Profiling",
• data.type = "Gene Expression Quantification",
• experimental.strategy = "RNA-Seq",
• workflow.type = 'HTSeq - FPKM-UQ',
• sample.type = c("Blood Derived Normal")) Error in GDCquery(project = "TCGA-BRCA", legacy = FALSE, data.category = "Transcriptome Profiling", : could not find function "GDCquery"