Arthur Rand

@wietingj Others have [asked](https://github.com/nanoporetech/modkit/issues/232) for this functionality as well, it'll get into the next big release.

@lance0499 Not yet, should be in the next major release.

Hello @Yang990-sys , @lance0499 , @wietingj As of [v0.4.0](https://github.com/nanoporetech/modkit/releases/tag/v0.4.0) when you use the same sample name in `modkit dmr multi` the samples will be combined. I'm working on some other...

Hello @handoko12u, The most likely cause is you're running out of memory. Does the infrastructure you're running on have a hard limit? Maybe you could increase it. If you can...

@handoko12u, I don't have a simple way to determine _a priori_ how much memory the analysis will take. Could you tell me how much RAM your machine has with `free...

Hello @handoko12u, Sorry for being slow to get back. I would recommend sharding the input bedMethyl into genomic regions, (i.e. by chromosome or total length) and running each shard separately....

Hello @handoko12u , Could you tell me the number of rows and/or the size of the bedMethyl files you're using? `/var/lib/minknow/data/20230907_LSK114_KNF_DNA_Long/4562949_ReRun1/modkit/bedmethyl.bed.gz` and `/var/lib/minknow/data/20231122_LSK114_KNF_DNA_Short/4597620/modkit/methyl.bed.gz` as well as the size of the...

@handoko12u, The [latest](https://github.com/nanoporetech/modkit/releases/tag/v0.2.5) version of modkit should use less memory when doing single-site DMR. Please give it a try at your convenience.

Hello @ddubocan, The problem comes from Dorado 0.5.1 would not set this value correctly. Normally I would say that you could manually fix the MN tag with something like pysam,...

@ddubocan any luck?