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Published 20 hours ago • verified publisher icon zhengxwen

Question: Genotype QC for training

Open adiamb opened this issue 4 years ago • 1 comments

Since many snps in the HLA region typically don't obey the HWE, do you recommend not applying a HWE filter for quality control steps before doing the training? can you advice please? thank you

adiamb avatar Aug 11 '21 19:08 adiamb

No need to use HWE filter in QC, the HIBAG algorithm is robust to the departure of HWE.

zhengxwen avatar Aug 19 '21 05:08 zhengxwen