Haystack Heuristic

[rbharath]

https://www.nature.com/articles/s41598-017-04439-5

A cool paper that shows how a simple heuristic can find disease motifs in a dataset of B-cell receptor sequences drawn from (roughly) 50 healthy patients and 50 unhealthy patients.

A simple deep-learned version of such a model might use a 1D conv-net to predict from sequence to patient healthy/unhealthy state.

Would it be possible to get access to the data as a public resource?

[lapeltsin]

The data is publicly available at http://www.immport.org/immport-open/public/study/study/displayStudyDetail/SDY1043

[vsomnath]

Should try testing DeepMHC on these datasets.