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Tracer plots for LDhat run

Open Homap opened this issue 3 years ago • 1 comments

Hello,

I ran interval on 2000 SNPs of a region about 300 Kb. I have 10 diploid individuals. I ran interval with block penalty of 5, 10 million iterations and sampled every 2000 steps. I use a subset of likelihood table for 20 haplotypes and a theta of 0.001. The pi in my samples is about 0.002 and theta is very close to it.

Screenshot 2022-06-14 at 10 56 14 Screenshot 2022-06-14 at 10 56 21 Screenshot 2022-06-14 at 10 56 25

The effective sample sizes (ESS) are very low for likelihood and blocks and there is a large difference between their ESS and the one of map.

Sorry as this is a very general questions but I wonder if you have any suggestions on how I could improve this? Is it the matter of running the chain longer or some other potential issue? Could the likelihood table be the problem? Is there a difference in the likelihood table when using genotypes vs. haplotypes?

Thank you! Homa

Homap avatar Jun 14 '22 09:06 Homap

Very interesting, I just converted the length of region to Kb, keeping everything else constant. The result changed drastically:

Screenshot 2022-06-14 at 11 44 52 Screenshot 2022-06-14 at 11 45 00 Screenshot 2022-06-14 at 11 45 03

Why would this change the output? It's really interesting.

Homap avatar Jun 14 '22 09:06 Homap